
Journal of Organic Chemistry p. 2715 - 2723 (1994)
Update date:2022-08-05
Topics:
Voss, James J. De
Hangeland, Jon J.
Townsend, Craig A.
Starting from D-(-)-ribose, a set of synthetic routes sharing common intermediates has been developed and exemplified in <5'-(2)H2>-, <4'-(2)H>-, <1'-(2)H>-, (5'R)-<5'-(2)H>-, and (5'S)-<5'-(2)H>-N4-benzoylcytidine and, by deoxygenation, their corresponding 2'-deoxynucleosides.These syntheses provide convenient access to millimolar quantities of deuterium/tritium-labeled natural or unnatural nucleosides for direct use or automated oligonucleotide synthesis.
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Doi:10.1039/J19690002145
()Doi:10.1021/ma4025416
(2014)Doi:10.1021/om500084j
(2014)Doi:10.1055/s-1994-25424
(1994)Doi:10.1021/jo00086a054
(1994)Doi:10.1039/c3cc49026b
(2014)