General Approach to the Synthesis of Specifically Deuterium-Labeled Nucleosides

Article abstract of DOI:10.1021/jo00089a013

Starting from D-(-)-ribose, a set of synthetic routes sharing common intermediates has been developed and exemplified in <5'-(2)H2>-, <4'-(2)H>-, <1'-(2)H>-, (5'R)-<5'-(2)H>-, and (5'S)-<5'-(2)H>-N⁴-benzoylcytidine and, by deoxygenation, their corresponding 2'-deoxynucleosides.These syntheses provide convenient access to millimolar quantities of deuterium/tritium-labeled natural or unnatural nucleosides for direct use or automated oligonucleotide synthesis.