1549877-10-2

Upstream product

• 20839-81-0 (2,4-dimethoxybenzylamino)acetic acid methyl ester 
• 1549876-96-1 11-(2,4-dimethoxybenzyl)-4-phenyl-3,9-dihydro-3,9a-(epiminomethano)indeno[2,1-b]-pyridine-2,10(1H)-dione 
• 1482501-67-6 11-(2,4-dimethoxybenzyl)-2-methoxy-4-phenyl-3,9-dihydro-3,9a-(epiminomethano)indeno-[2,1-b]pyridin-10-one 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 1549877-15-7 4-phenyl-2,9-dihydro-1H-indeno[2,1-c]pyridin-1-one 

Relevant academic research and scientific papers

Synthesis of 2-pyridones by cycloreversion of [2.2.2]- bicycloalkene diketopiperazines

A general strategy for the conversion of [2.2.2]-diazabicyclic alkene structures to 2-pyridone aromatic heterocyclic products is reported. The reaction sequence starts from 2,5-diketopiperazine (DKP) derivatives, is compatible with both aromatic and aliphatic aldehyde components, and can intercept either intra- or intermolecular cycloaddition manifolds. Priming of one aza-bridging function in the intermediate [2.2.2]-DKP scaffold permits cycloreversion (microwave heating) and selective extrusion of cyanate derivatives leading to the formation of 2-pyridone structures. Progress toward the synthesis of louisianin A and B, antiproliferative 2-pyridone natural products, is also disclosed.