20839-81-0

Basic information

• Product Name: Glycine, N-[(2,4-dimethoxyphenyl)methyl]-, methyl ester
• CAS NO: 20839-81-0
• Molecular Formula: C12H17NO4
• Molecular Weight: 239.271
• Mol File: 20839-81-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Glycine, N-[(2,4-dimethoxyphenyl)methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[(2,4-dimethoxyphenyl)methyl]-, methyl ester(20839-81-0)
• EPA Substance Registry System: Glycine, N-[(2,4-dimethoxyphenyl)methyl]-, methyl ester(20839-81-0)

Safety Data

• Hazardous Substances Data: 20839-81-0(Hazardous Substances Data)

Upstream product

• 20781-20-8 2,4-Dimethoxybenzylamine 
• 96-34-4 methyl chloroacetate 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 96-32-2 bromoacetic acid methyl ester 
• 67-56-1 methanol 
• 20839-79-6 (2,4-dimethoxy-benzylamino)-acetic acid 

Downstream Products

• 92685-85-3 [((2S,3R)-2-Bromo-3-hydroxy-butyryl)-(2,4-dimethoxy-benzyl)-amino]-acetic acid methyl ester 
• 1133435-54-7 3-{[(2,4-dimethoxybenzyl)ethoxycarbonylmethylamino]methyl}benzo[b]thiophene-2-carboxylic acid methyl ester 

Relevant articles and documents

NITROXOLINE PRODRUG AND USE THEREOF

Provided are a nitroxoline prodrug and a use thereof. Specifically, provided are a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, a composition containing the compound, and a use thereof in the preparation of anti-infective and antitumor drugs, and definitions of groups in formula (I) are as stated in the specification. The compound represented by formula (I) has better pharmacokinetic parameters such as solubility, blood medicine concentration, or half-life period than nitroxoline. The compound represented by formula (I) can reduce the frequency of drug administration, and has potential for application in other fields other than the field of urinary tracts.

PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION

Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.

Synthesis of 2-pyridones by cycloreversion of [2.2.2]- bicycloalkene diketopiperazines

A general strategy for the conversion of [2.2.2]-diazabicyclic alkene structures to 2-pyridone aromatic heterocyclic products is reported. The reaction sequence starts from 2,5-diketopiperazine (DKP) derivatives, is compatible with both aromatic and aliphatic aldehyde components, and can intercept either intra- or intermolecular cycloaddition manifolds. Priming of one aza-bridging function in the intermediate [2.2.2]-DKP scaffold permits cycloreversion (microwave heating) and selective extrusion of cyanate derivatives leading to the formation of 2-pyridone structures. Progress toward the synthesis of louisianin A and B, antiproliferative 2-pyridone natural products, is also disclosed.