155-10-2

Usage

Uses

Used in Pharmaceutical Research and Development:
4-Amino-2-chloro-5-fluoropyrimidine is used as a key intermediate in the synthesis of various drugs, particularly those with antiviral and anticancer activities. Its unique structure allows for the creation of new therapeutic agents that can target specific biological pathways, potentially leading to more effective treatments for viral infections and cancer.
Used in Agrochemical Production:
4-Amino-2-chloro-5-fluoropyrimidine is also utilized as a building block in the production of agrochemicals, which are chemicals specifically designed to benefit crop production and control pests. The versatility of 4-Amino-2-chloro-5-fluoropyrimidine in chemical synthesis makes it a valuable component in the development of new agrochemicals that can improve agricultural yields and protect crops from damage.
Used in the Production of Fine Chemicals:
4-Amino-2-chloro-5-fluoropyrimidine is employed as a fundamental component in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, including the fragrance, flavor, and specialty chemical industries. Its presence in these compounds can contribute to the development of new products with enhanced properties and performance.

InChI:InChI=1/C4H3ClFN3/c5-4-8-1-2(6)3(7)9-4/h1H,(H2,7,8,9)

Upstream product

• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 

Downstream Products

• 1174376-12-5 2-(3-Bromobenzyloxy)-5-fluoropyrimidin-4-ylamine 
• 1174376-13-6 5-fluoro-2-[1-(4-fluorophenyl)ethoxy]pyrimidin-4-ylamine 
• 1174376-11-4 5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4 amine 
• 1174376-14-7 1-phenylethanone-O-(4-amino-5-fluoropyrimidin-2-yl)oxime 
• 1595144-14-1 (R)-1-(4-amino-5-fluoropyrimidin-2-yl)-N-(4-chlorophenylethyl)piperidine-3-carboxamide 
• 1174376-25-0 5-fluoro-2-(4-methylbenzyloxy)pyrimidin-4-amine 
• 455266-06-5 5-Fluoro-N₂-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrimidine-2,4-diamine 
• 1174379-10-2 C₁₂H₁₂FN₃O₂ 

Relevant academic research and scientific papers

Synthesis, conformation and biological properties of selenonucleosides

Synthesis, conformation and antitumour properties of novel 2- and 4- selenopyrimidine nucleosides are described.

ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF

The present invention relates to isoxazolidines of formula I and their use as receptor-interacting protein kinase 1 inhibitors, for example in the treatment of diseases and disorders mediated by RIP kinase (1) such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease (IBD), Crohn's disease or ulcerative colitis.

Flucytosine preparation method applicable to industrial production

The invention discloses a flucytosine preparation method applicable to industrial production. The method comprises the following steps: performing chlorination on fluorouracil, performing ammonification, and performing hydrolysis, thereby obtaining flucytosine. To solve defects, the invention provides the flucytosine preparation method applicable to industrial production, and the method is small in process procedure, simple in operation, low in investment cost, relatively good in prospect and applicable to large-scale industrial production.

SYNTHESIS AND AMINATION OF 2,4-DICHLORO-5-FLUOROPYRIMIDINE

2,4-Dichloro-5-fluoropyrimidine was prepared by the chlorination of 5-fluorouracil with phosphorus pentachloride in absence of solvent.The reaction of 2,4-dichloro-5-pyrimidine with primary and secondary aliphatic and heteroaromatic amines in an aqueous medium yields 2-chloro-4-RR'-amino-5-fluoropyrimidines, with stereoselective substitution of chlorine in the C4 position.The substances obtained have well-defined fungicidal activity.