155-10-2

Basic information

• Product Name: 4-Amino-2-chloro-5-fluoropyrimidine
• Synonyms: 2-CHLORO-4-AMINO-5-FLUOROPYRIMIDINE;4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE;4-Pyrimidinamine, 2-chloro-5-fluoro- (9CI);2-Chloro-5-fluoro-4-pyrimidinamine;2-chloro-5-fluoro-pyrimidin-4-ylamine;4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE GC 95.0%;2-chloro-4-animo-5-fluoropyrimidine;2-Chloro-5-fluoropyrimidine-4-amine
• CAS NO: 155-10-2
• Molecular Formula: C₄H₃ClFN₃
• Molecular Weight: 147.54
• Product Categories: PYRIMIDINE;pharmacetical;API intermediates;Activity;Enzyme Substrates;Fluorogenic;Fluorine series
• Mol File: 155-10-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 193.0 to 197.0 °C
• Boiling Point: 318.463 ºC at 760 mmHg
• Flash Point: 146.401 ºC
• Appearance: White to light yellow/Crystalline Powder
• Density: 1.564 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: soluble in Dimethylformamide
• PKA: 0.96±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-2-chloro-5-fluoropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-chloro-5-fluoropyrimidine(155-10-2)
• EPA Substance Registry System: 4-Amino-2-chloro-5-fluoropyrimidine(155-10-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 155-10-2(Hazardous Substances Data)

Usage

General Description

4-Amino-2-chloro-5-fluoropyrimidine is a chemical compound that is commonly used as an intermediate in organic synthesis. It is a heterocyclic compound consisting of a pyrimidine ring with an amino group at the 4-position, a chlorine atom at the 2-position, and a fluorine atom at the 5-position. 4-Amino-2-chloro-5-fluoropyrimidine is often used in pharmaceutical research and development for the synthesis of various drugs, including antiviral and anticancer agents. It is also used as a building block for the production of agrochemicals and other fine chemicals. 4-Amino-2-chloro-5-fluoropyrimidine is an important chemical with a wide range of applications in various industries.

InChI:InChI=1/C4H3ClFN3/c5-4-8-1-2(6)3(7)9-4/h1H,(H2,7,8,9)

Upstream product

• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 

Downstream Products

• 1174376-13-6 5-fluoro-2-[1-(4-fluorophenyl)ethoxy]pyrimidin-4-ylamine 
• 1174376-11-4 5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4 amine 
• 1174376-14-7 1-phenylethanone-O-(4-amino-5-fluoropyrimidin-2-yl)oxime 
• 1174376-25-0 5-fluoro-2-(4-methylbenzyloxy)pyrimidin-4-amine 
• 1174379-10-2 C₁₂H₁₂FN₃O₂ 
• 1595144-14-1 (R)-1-(4-amino-5-fluoropyrimidin-2-yl)-N-(4-chlorophenylethyl)piperidine-3-carboxamide 
• 1174376-12-5 2-(3-Bromobenzyloxy)-5-fluoropyrimidin-4-ylamine 
• 455266-06-5 5-Fluoro-N₂-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrimidine-2,4-diamine 

Relevant articles and documents

Synthesis, conformation and biological properties of selenonucleosides

Synthesis, conformation and antitumour properties of novel 2- and 4- selenopyrimidine nucleosides are described.

Flucytosine preparation method applicable to industrial production

The invention discloses a flucytosine preparation method applicable to industrial production. The method comprises the following steps: performing chlorination on fluorouracil, performing ammonification, and performing hydrolysis, thereby obtaining flucytosine. To solve defects, the invention provides the flucytosine preparation method applicable to industrial production, and the method is small in process procedure, simple in operation, low in investment cost, relatively good in prospect and applicable to large-scale industrial production.