155-11-3

Basic information

• Product Name: 2,4-Pyrimidinediamine, 5-fluoro- (9CI)
• Synonyms: 2,4-Pyrimidinediamine, 5-fluoro- (9CI);(2-amino-5-fluoro-pyrimidin-4-yl)amine;5-fluoropyrimidine-2,4-diamine
• CAS NO: 155-11-3
• Molecular Formula: C4H5FN4
• Molecular Weight: 128.1077032
• Product Categories: PYRIMIDINE
• Mol File: 155-11-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 376.4°Cat760mmHg
• Flash Point: 181.4°C
• Appearance: /
• Density: 1.513g/cm³
• Vapor Pressure: 7.28E-06mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 2,4-Pyrimidinediamine, 5-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pyrimidinediamine, 5-fluoro- (9CI)(155-11-3)
• EPA Substance Registry System: 2,4-Pyrimidinediamine, 5-fluoro- (9CI)(155-11-3)

Safety Data

• Hazardous Substances Data: 155-11-3(Hazardous Substances Data)

Usage

General Description

2,4-Pyrimidinediamine, 5-fluoro- (9CI) is a chemical compound that belongs to the class of pyrimidine derivatives. It is a fluorinated derivative of 2,4-pyrimidinediamine and is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs. This chemical is known for its potential to act as an antitumor and antiviral agent, making it of interest for medical research and drug development. Additionally, it has been investigated for its potential use as an anti-inflammatory and immunosuppressive agent. However, its specific biological activities and potential toxicity require further study for its safe and effective use in pharmaceutical applications.

InChI:InChI=1/C4H5FN4/c5-2-1-8-4(7)9-3(2)6/h1H,(H4,6,7,8,9)

Upstream product

• 593-85-1 guanidine carbonate 
• 50-01-1 guanidine hydrochloride 
• 124-46-9 guanidine hydrogen carbonate 
• 593-85-1 diguanidine carbonate 

Relevant articles and documents

Synthesis of 5-Fluorocytosine Using 2-Cyano-2-fluoroethenolate as a Key Intermediate

There is an urgent demand for 5-fluorocytosine (5-FC) due to its activity against HIV-induced fungal infections as well as its use as a key intermediate in the synthesis of the clinically highly important anti-HIV drug emtricitabine (FTC). We report a simple, low-cost five steps synthesis of 5-FC starting from chloroacetamide. Overall yields up to 46 % were achieved and the route is devoid of any chromatographic purifications. The previously unknown key intermediate (Z)-2-cyano-2-fluoroethenolate is obtained through a Claisen-type condensation from fluoroacetonitrile. As the direct cyclization with urea only gave poor yields, 5-fluoro-2-methoxypyrimidin-4-amine, 5-fluoro-2-(methylsulfanyl)pyrimidin-4-amine and 5-fluoropyrimidine-2,4-diamine served as synthetic intermediates.

2-CYANO-2-FLUOROETHENOLATE SALTS (CFES): VERSITILE ACTIVE PHARMACEUTICAL INTERMEDIATES

The present invention relates to new enolate structures with utility as active pharmaceutical intermediates for the preparation of efficacious drugs such as those derived from 5-fluorocytosine (5-FC).