15501-17-4

Upstream product

• 62-53-3 aniline 
• 635-93-8 5-chlorosalicyclaldehyde 

Downstream Products

• 7123-49-1 4-chloro-2-(phenylaminomethyl)phenol 
• 51892-04-7 3,4-dihydro-3-phenyl-6-chloro-2H-1,3-benzoxazine 
• 1323141-89-4 diethyl 5-chloro-3-(phenylamino)benzofuran-2,2(3H)-dicarboxylate 
• 90759-54-9 Pt(OC₆H₃ClCHNC₆H₅)2 
• 1360873-56-8 (3aS,4R,9aR)-6-chloro-N-phenyl-3,3a,4,9a-tetrahydro-2H-furo[2,3-b]chromen-4-amine 
• 1026718-72-8 (3aR,4S,9aS)-6-chloro-N-phenyl-3,3a,4,9a-tetrahydro-2H-furo[2,3-b]chromen-4-amine 

Relevant academic research and scientific papers

Synthesis and evaluation of oxovanadium(iv) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted- benzenamine as selective inhibitors of protein tyrosine phosphatase 1B

Five oxovanadium(iv) complexes, which were divided into two groups, [V IVO(bhbb, nhbb)(H2O)2] (tridentate ligands: H2bhbb = 2-(5-bromo-2-hydroxylbenzylideneamino)benzoic acid, 1; H2nhbb = 2-(5-nitro-2

Copper-Catalyzed Asymmetric Annulation Reactions of Carbenes with 2-Iminyl- or 2-Acyl-Substituted Phenols: Convenient Access to Enantioenriched 2,3-Dihydrobenzofurans

We have developed a method for the highly diastereo- and enantioselective construction of 2,3-dihydrobenzofurans bearing tetrasubstituted carbon stereocenters by means of annulation reactions between carbenes and 2-iminyl- or 2-acyl-substituted phenols through catalysis by readily accessible copper(I)/bisoxazoline catalysts under mild conditions. These reactions feature a unique mechanism in which the copper catalyst serves a dual function: first it reacts with the diazo compound to generate a metal carbene, and second, upon formation of an oxonium ylide, it acts as a Lewis acid to activate the imine or ketone for diastereo- and enantioselective cyclization.

Chalcone and flavonol copper(II) complexes containing schiff base co-ligand: Synthesis, crystal structures and catecholase-like activity

Four new heteroleptic copper(II) complexes having chalcone or flavonol ligands and Schiff base (N-phenyl-5-chlorosalicylideneimine) as co-ligand were prepared, chemically and structurally characterized and investigated as functional biomimetic catecholase models. The complexes were prepared by the solution synthesis and crystal and molecular structures were determined by X-ray diffraction. Complexes were chemically characterized by elemental analysis, infrared and electronic absorption spectroscopy as well as by electrochemical measurements. Copper(II) chalcone complexes, with square-pyramidal CuO4N core, are binuclear, featuring phenolate oxygen from the Schiff base as a bridging atom, while copper(II) flavonol complexes are mononuclear, and reveal a square planar CuO3N coordination core. Catalytic activity of the complexes in 3,5-di-tert-butylcatechol oxidation was confirmed by spectrophotometric and electrochemical measurements. Kinetic measurements revealed that the binuclear (chalcone-containing) complexes have enhanced catalytic activity as compared to the mononuclear Cu(II) flavonol complexes. Relatively high kcat values (300 – 750 h–1) confirmed their respectable biomimetic catecholase-like activity.

Carbocation Organocatalysis in Interrupted Povarov Reactions to cis-Fused Pyrano- and Furanobenzodihydropyrans

Tritylium cation-catalyzed interrupted Povarov reactions afforded cis-4-aminobenzodihydropyrans in excellent yields (90 %) within 10 min by low catalyst loadings (1 mol-%). A mechanism involving Lewis acidic catalysis by a carbocation was proposed and val

Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease

A series of imine resveratrol derivatives (1-20) have been designed, synthesized, and evaluated as multi-targeted compounds for the treatment of Alzheimer's disease (AD). In vitro studies show that most of the molecules exhibit a significant ability to in

Synthesis and evaluation of copper complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatases

Five copper complexes, [Cu(bhbb,chbb,nhbb)(H2O)n] (tridentate-ligands: H2bhbb = 2-(5-bromo-2-hydroxylbenzylideneamino) benzoic acid, 1; H2chbb = 2-(5-chloro-2-hydroxylbenzylideneamino) benzoic acid, 2; H2/

DNA binding properties of two ruthenium(III) complexes containing schiff bases derived from salicylaldehyde: Spectroscopic and electrochemical evidence of CT DNA intercalation

The interaction of CT DNA by two anionic Ru(III) complexes with N-substituted salicylidenimine ligands was investigated by spectroscopic titration and cyclic voltammetry. The result gives a surprising evidence for intercalation of DNA by the negatively ch

The use of Cu and Zn salicylaldimine complexes as catalyst precursors in ring opening polymerization of lactides: Ligand effects on polymer characteristics

A range of monomeric tetra-coordinate copper (II) and zinc (II) complexes based on N,O-bidentate salicylaldimine Schiff base ligands has been synthesized and characterized using various spectroscopic techniques. These complexes were then evaluated as init

Catalytic asymmetric mannich-ketalization reaction: Highly enantioselective synthesis of aminobenzopyrans

"Chemical Equation Present" Domino catalysis: We have developed the first enantioselective domino Mannich-ketalization reaction of o-hydroxy benzaldimines with electron-rich alkenes (see scheme). The new reaction sequence provides an easy and direct acces

The synthesis of copper(II) salicylaldiminato complexes and their catalytic activity in the hydroxylation of phenol

The synthesis of copper(II) salicylaldiminato complexes and their application in the catalytic hydroxylation of phenol is reported. Tetracoordinated copper complexes (Cu(Ln)2) were obtained by reacting the N-phenylsalicylaldimine ligands (HL1 -HL7) with copper acetate in a 2:1 mole ratio. The reaction of N-(2,6-diisopropyl) phenyl-3,5-di-tert-butylsalicylaldimine (HL7) with copper acetate in a 1:1 mole ratio afforded a dinuclear complex, which was not obtained with the other ligand systems. All complexes were characterized using FT-IR and elemental analysis. X-Ray crystal structures of complexes 2, 5 and 8 have also been obtained. The catalytic activity of these complexes was evaluated in the hydroxylation of phenol using oxygen and hydrogen peroxide as co-oxidants in aqueous media in the pH range 3-6. AU complexes studied were found to be active for the hydroxylation process over the pH range studied with higher selectivity for catechol formation.