155062-48-9

Usage

Chemical family

Belongs to the oxadiazole family, which is a group of five-membered heterocyclic compounds containing two nitrogen atoms and one oxygen atom.

Structure

A carbonyl chloride derivative with a methyl group attached to the 5th carbon atom.

Potential applications

Has potential applications in the field of organic synthesis and pharmaceuticals due to its unique structure and reactivity.

Building block

Can be used as a building block for the synthesis of various organic compounds and pharmaceutical drugs.

Reagent

May have potential use as a reagent in chemical reactions.

Precursor

Can serve as a precursor for the development of new materials.

Further research

Its specific uses and applications would depend on further research and development in the field.

Molecular weight

Approximately 156.54 g/mol (calculated from the chemical formula)

Appearance

The appearance of the compound is not provided in the material, but it is likely a solid or a liquid depending on its stability and purity.

Stability

The stability of the compound is not mentioned in the material, but it is important to consider when working with reactive compounds like carbonyl chlorides.

Safety precautions

The safety precautions and potential hazards associated with handling and using 1,2,4-Oxadiazole-3-carbonyl chloride, 5-methyl- (9CI) are not provided in the material, but it is crucial to follow proper safety protocols when working with potentially reactive chemicals.

Upstream product

• 155062-49-0 5-methyl-1,2,4-oxadiazole-3-carboxylic acid sodium salt 
• 20615-94-5 potassium 5-methyl-1,2,4-oxadiazole-3-carboxylate 

Relevant academic research and scientific papers

The discovery of MK-4256, a potent SSTR3 antagonist as a potential treatment of type 2 diabetes

A structure-activity relationship study of the imidazolyl-β- tetrahydrocarboline series identified MK-4256 as a potent, selective SSTR3 antagonist, which demonstrated superior efficacy in a mouse oGTT model. MK-4256 reduced glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po. As compared with glipizide, MK-4256 showed a minimal hypoglycemia risk in mice.

Route development and multikilogram GMP delivery of a somatostatin receptor antagonist

Route development and demonstration on multikilogram scale for the first GMP delivery of MK-4256 are described. Key aspects of the convergent route include a regioselective green iodination, one-pot oxadiazole synthesis, and an efficient ketone Pictet-Spengler reaction with diastereomeric upgrade via crystallization to afford 6 kg of API. A recycle procedure augmented the yield of desired diastereomer in the Pictet-Spengler reaction from a mixture of diastereomers heavily enriched in the undesired diastereomer.

Substituted sulphonyl amino(thio)carbonyl compounds and their use as herbicides

The invention relates to novel sulfonylamino(thio)carbonyl compounds of the formula (I), in whichn represents the numbers 0, 1 or 2,A represents a single bond, or oxygen or sulfur, or the grouping N—R, in which R represents hydrogen, alkyl, alkenyl, alkin