20615-94-5

Usage

Uses

Used in Agricultural Applications:
Potassium 5-methyl-1,2,4-oxadiazole-3-carboxylate is used as a pesticide and insecticide for its effectiveness in controlling pests and insects. It is valued in agriculture for its ability to protect crops from damaging infestations while exhibiting low toxicity to mammals, ensuring the safety of both the environment and the consumers.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, potassium 5-methyl-1,2,4-oxadiazole-3-carboxylate serves as a key intermediate in the synthesis of various pharmaceuticals and drugs. Its chemical structure contributes to the development of new medicinal compounds, potentially enhancing treatment options and therapeutic outcomes.
It is crucial to handle potassium 5-methyl-1,2,4-oxadiazole-3-carboxylate with care, adhering to proper safety protocols during its use in both agricultural and pharmaceutical applications to minimize any potential risks.

Upstream product

• 19703-94-7 methyl 5-methyl-1,2,4-oxadiazole-3-carboxylate 
• 40699-38-5 5-methyl-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester 

Downstream Products

• 155062-48-9 5-methyl-1,2,4-oxadiazole-3-carbonyl chloride 

Relevant academic research and scientific papers

POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS

The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).

COMPOUNDS AS HEPATITIS C INHIBITORS AND USES THEREOF IN MEDICINE

Provided herein are compounds as hepatitis C inhibitors and uses thereof in medicine. Specifically, provided herein is a compound of Formula (I) or a stereoisomer, a tautomer, an enantiomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or hepatitis C diseases. Also provided herein are a pharmaceutically acceptable composition containing such compound and a method of treating HCV infection or hepatitis C diseases comprising administering the compound or pharmaceutical composition thereof disclosed herein.

Novel bi-cyclic or tri-cyclic heterocyclic compound

The present invention provides novel bi-cyclic or tri-cyclic compound represented by formula (I) or pharmaceutical acceptable salt thereof, [wherein, ring A is an aromatic group which may be substituted, one of X1 and X2 is a carbon atom, and another is a nitrogen atom, X3 is a nitrogen atom or CR2, X4 is a nitrogen atom or CR3, X5 is a sulfur atom or -CH=CH-, Z1 is an oxygen atom, -C(R6)(R7)-, -NH-, -C(R6)(R7)-NH-, -NH-C(R6)(R7)-, -C(R6)(R7)-O-, -O-C(R6)(R7)- or a single bone, one of Z2 and Z3 is CH and another one is a nitrogen atom, or both are nitrogen atoms, the other symbols are same as those defined in the specification.]

Route development and multikilogram GMP delivery of a somatostatin receptor antagonist

Route development and demonstration on multikilogram scale for the first GMP delivery of MK-4256 are described. Key aspects of the convergent route include a regioselective green iodination, one-pot oxadiazole synthesis, and an efficient ketone Pictet-Spengler reaction with diastereomeric upgrade via crystallization to afford 6 kg of API. A recycle procedure augmented the yield of desired diastereomer in the Pictet-Spengler reaction from a mixture of diastereomers heavily enriched in the undesired diastereomer.