155085-04-4Relevant academic research and scientific papers
Studies in antiparasitic agents: Part 20 - Synthesis of probenzimidazoles, benzimidazoles and purimidobenzimidazoles as possible anthelmintics
Srivastava, Ravi P.,Singh, Sudhir K.,Abuzar, Syed,Sharma, Satyavan,Gupta, Suman,et al.
, p. 1035 - 1044 (2007/10/02)
A series of tetrasubstituted benzophenones (1-35) have been synthesized as probenzimidazoles.Some 2,5-disubstituted benzimidazoles (36-39 and 43-61) and pyrimidobenzimidazoles (40-42) have also been prepared.Of these compounds 4, 5, 15, 27, 29, 30, and 51 exhibit 100percent antihookworm activity against A. ceylanicum in hamsters at an oral dose of 250 mg/kg*3 while compounds 3, 4, 26-30 cause 100percent elimination of tapeworms, H. nana at a dose of 250 mg/kg.Compound 4 kills 90percent of the microfilariae of L. carinii at an intraperitoneal dose of 30 mg/kg*5.Another compound, 48 shows 6 4-78percent microfilaricidal and 38-62percent macrofilaricidal action against L. carinii and B. malayi at a dose of 50 mg/kg*5.
