155088-51-0

Basic information

• Product Name: 3-nitro-4-phenylisoxazole
• Synonyms: 3-nitro-4-phenylisoxazole
• CAS NO: 155088-51-0
• Molecular Weight: 190.158
• Mol File: 155088-51-0.mol

Chemical Properties

• CAS DataBase Reference: 3-nitro-4-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-nitro-4-phenylisoxazole(155088-51-0)
• EPA Substance Registry System: 3-nitro-4-phenylisoxazole(155088-51-0)

Safety Data

• Hazardous Substances Data: 155088-51-0(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 100-52-7 benzaldehyde 

Downstream Products

• 182424-34-6 3-amino-4-phenyl isoxazole 
• 182424-31-3 N-(4-phenylisoxazol-3-yl)hydroxylamine 

Relevant articles and documents

Synthesis of 3-Nitroisoxazoles via Copper Acetate-Mediated Reaction of Benzaldehydes with Nitromethane

A copper acetate-mediated reaction of benzaldehydes with nitromethane to synthesis of 3-nitroisoxazoles is reported. A variety of nitro-aryl-disubstituted isoxazole derivatives can be prepared in moderate to good yields with benign functional group tolera

Heterocyclic synthetic method for 4-aryl-3-nitro isoxazole by using copper salt to catalyze aryl aldehyde and nitromethane

The invention discloses a heterocyclic synthetic method for 4-aryl-3-nitro isoxazole by using copper salt to catalyze aryl aldehyde and nitromethane. According to the method, a heterocyclic reaction is carried out on aryl aldehyde and nitromethane in an organic solution system containing copper acetate and ammonium iodide, so that 4-aryl-3-nitro isoxazole is obtained; the method is mild in reaction condition, cheap in catalyst and raw materials and high in reaction yield, and is beneficial for industrial production.

Method using copper salt to catalyze heterocyclization of aromatic aldehyde and nitromethane to synthesize isoxazole derivative

The invention discloses a method using copper salt to catalyze the heterocyclization of aromatic aldehyde and nitromethane to synthesize an isoxazole derivative. The method is characterized in that the aromatic aldehyde and the nitromethane are allowed to have aromatic aldehyde and nitromethane in an organic solution system containing copper acetate and iodized salt so as to prepare the isoxazolederivative. The method is mild in reaction condition, cheap in catalyst and raw materials, high in reaction yield and beneficial to industrial production.

Synthetic method of 3-nitroisoxazole derivative

The invention discloses a synthetic method of a 3-nitroisoxazole derivative. The method comprises the step of carrying out heterocyclization on aryl aldehyde and nitromethane in an alcoholic solutionsystem which contains copper acetate and iodine salt to obtain the 3-nitroisoxazole derivative. The method is gentle in reaction condition, a catalyst and raw materials are low in price, the reactionyield is high, and industrial production is facilitated.

Nitroisoxazoles by manganese(IV) oxide oxidation of nitro-4,5-dihydroisoxazoles

Aryl and alkyl substituted 3- and 5-nitroisoxazole derivatives were prepared from the appropriate 3- and 5-nitro-4,5-dihydroisoxazoles using manganese(IV) oxide as oxidizing agent. Some of the 3-nitro-4-substituted isoxazoles were prepared directly by rea