1551-14-0

Usage

Explanation

1H-Pyrrole, 2-hexylconsists of 10 carbon atoms, 17 hydrogen atoms, and 1 nitrogen atom.
2. Aromatic heterocycle

Explanation

The compound has a five-membered ring structure with a nitrogen atom, making it an aromatic heterocycle.
3. Derivative of pyrrole

Explanation

1H-Pyrrole, 2-hexylis derived from the base structure of pyrrole, which is a simple five-membered aromatic heterocycle.
4. 2-hexyl substitution

Explanation

A hexyl group, a six-carbon alkyl chain, is attached to the second position of the pyrrole ring, giving the compound its unique properties.
5. Applications in synthesis

Explanation

1H-Pyrrole, 2-hexylis used in the synthesis of pharmaceuticals, agrochemicals, and polymer additives.
6. Building block for organic synthesis

Explanation

The compound serves as a starting point or intermediate in the synthesis of more complex organic molecules.
7. Research laboratory use

Explanation

Due to its unique chemical properties and reactivity, 1H-Pyrrole, 2-hexylis used in research laboratories for various studies and experiments.
8. Potential industrial applications

Explanation

The compound's chemical structure and properties may lead to its use in various industrial applications.

Upstream product

• 89789-54-8 2-hexanoylpyrrole 
• 142-62-1 hexanoic acid 
• 13257-44-8 1,1-dimethoxy-2-nonyne 
• 81113-11-3 3-methoxy-2-decynenitrile 
• 5830-30-8 N,N-dimethylhexanamide 
• 81112-98-3 2-methoxy-3-decynylamine 
• 142-61-0 Hexanoyl chloride 

Downstream Products

• 89789-81-1 (4-Benzyloxycarbonylamino-decyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Gold(I)-catalyzed intramolecular acetylenic Schmidt reaction

Substituted pyrroles were prepared by a gold(I)-catalyzed acetylenic Schmidt reaction of homopropargyl azides. The reaction allows for regiospecific substitution at each position of the pyrrole ring under mild conditions. A mechanism in which azides serve as nucleophiles toward gold(I)-activated alkynes with subsequent gold(I)-aided expulsion of dinitrogen is proposed. Copyright

Neutrophil-Selective Fluorescent Probe Development through Metabolism-Oriented Live-Cell Distinction

Human neutrophils are the most abundant leukocytes and have been considered as the first line of defence in the innate immune system. Selective imaging of live neutrophils will facilitate the in situ study of neutrophils in infection or inflammation events as well as clinical diagnosis. However, small-molecule-based probes for the discrimination of live neutrophils among different granulocytes in human blood have yet to be reported. Herein, we report the first fluorescent probe NeutropG for the specific distinction and imaging of active neutrophils. The selective staining mechanism of NeutropG is elucidated as metabolism-oriented live-cell distinction (MOLD) through lipid droplet biogenesis with the help of ACSL and DGAT. Finally, NeutropG is applied to accurately quantify neutrophil levels in fresh blood samples by showing a high correlation with the current clinical method.

Antimalarial activity of natural and synthetic prodiginines

Prodiginines are a family of linear and cyclic oligopyrrole red-pigmented compounds. Herein we describe the in vitro antimalarial activity of four natural (IC50 = 1.7-8.0 nM) and three sets of synthetic prodiginines against Plasmodium falciparum. Set 1 compounds replaced the terminal nonalkylated pyrrole ring of natural prodiginines and had diminished activity (IC 50 > 2920 nM). Set 2 and set 3 prodiginines were monosubstituted or disubstituted at either the 3 or 5 position of the right-hand terminal pyrrole, respectively. Potent in vitro activity (IC50 = 0.9-16.0 nM) was observed using alkyl or aryl substituents. Metacycloprodiginine and more potent synthetic analogues were evaluated in a P. yoelii murine patent infection using oral administration. Each analogue reduced parasitemia by more than 90% after 25 (mg/kg)/day dosing and in some cases provided a cure. The most favorable profile was 92% parasite reduction at 5 (mg/kg)/day, and 100% reduction at 25 (mg/kg)/day without any evident weight loses or clinical overt toxicity.

PALLADIUM-CATALYZED SYNTHESIS OF PYRROLES

Pyrrole derivatives are prepared in high yields by the catalytic action of a Pd(II) salt on 1-amino-3-alkyn-2-ols which are obtained from conjugate ynones.