1551163-23-5

Basic information

• Product Name: methyl (S)-N-trityl-2-amino-4-bromobutanoate
• Synonyms: methyl (S)-N-trityl-2-amino-4-bromobutanoate
• CAS NO: 1551163-23-5
• Molecular Weight: 438.364
• Mol File: 1551163-23-5.mol

Chemical Properties

• CAS DataBase Reference: methyl (S)-N-trityl-2-amino-4-bromobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (S)-N-trityl-2-amino-4-bromobutanoate(1551163-23-5)
• EPA Substance Registry System: methyl (S)-N-trityl-2-amino-4-bromobutanoate(1551163-23-5)

Safety Data

• Hazardous Substances Data: 1551163-23-5(Hazardous Substances Data)

Upstream product

• 10332-17-9 Met-OMe 
• 76-83-5 trityl chloride 
• 15159-66-7 α-amino-γ-bromobutyric acid methyl ester hydrochloride 

Downstream Products

• 1551163-57-5 (S)-N-((1S,2R)-2-hydroxy-1,2-diphenylethyl)-1-tritylazetidine-2-carboxamide 
• 1551163-64-4 (S)-N-((1R,2S)-2-hydroxy-1,2-diphenylethyl)-1-tritylazetidine-2-carboxamide 
• 1551163-29-1 methyl (2S)-1-tritylazetidine-2-carboxylate 
• 1551163-35-9 triethylamine (2S)-1-tritylazetidine-2-carboxylate 
• 1551163-39-3 (S)-N-((S)-1-hydroxy-1,1-diphenylpropan-2-yl)-1-tritylazetidine-2-carboxamide 
• 1551163-42-8 (S)-N-((2S)-1-hydroxy-4-methyl-1,1-diphenylpentan-2-yl)-1-tritylazetidine-2-carboxamide 
• 1551163-45-1 (S)-N-((2S,3R)-1-hydroxy-3-methyl-1,1-diphenylpentan-2-yl)-1-tritylazetidine-2-carboxamide 

Relevant articles and documents

Enantioselective friedel-crafts alkylation of pyrrole with chalcones catalyzed by a dinuclear zinc catalyst

A highly enantioselective Friedel-Crafts (F-C) alkylation of pyrrole with a wide range of simple nonchelating chalcone derivatives catalyzed by a chiral (Zn2EtL)n (L = (S,S)-1) complex has been developed. The catalyst (Zn2EtL)n complex was prepared in situ by reacting the chiral ligand (S,S)-1 with 2 equiv of diethylzinc. A series of β-pyrrole-substituted dihydrochalcones were usually formed mostly in excellent yields (up to 99%) and excellent enantioselectivity [up to 99% enantiomeric excess (ee)] by using 15 mol % catalyst loading under mild conditions. The absolute stereochemistry of the products was determined to be the S-configuration by X-ray crystallographic analysis of 13g. Meanwhile, a weak negative nonlinear effect was observed. On the basis of the experimental results and previous reports, a possible mechanism was proposed to explain the origin of the asymmetric induction.

Enantiopure azetidine-2-carboxamides as organocatalysts for direct asymmetric aldol reactions in aqueous and organic media

A family of enantiopure azetidine-2-caboxamides was asymmetrically synthesized, and was examined as organocatalyst in direct aldol reactions. A well chosen chiral azetidine-2-caboxamide was found to smoothly catalyze the direct aldol reaction of various benzaldehydes with acetone in brine, and β-hydroxy ketones were produced with enantiomeric excess up to 96%. The reaction of benzaldehydes with cyclic ketones also led to the formation of anti-products in diastereomeric ratio up to 99:1 and enantiomeric excess up to 99%.