1551163-39-3

Basic information

• Product Name: (S)-N-((S)-1-hydroxy-1,1-diphenylpropan-2-yl)-1-tritylazetidine-2-carboxamide
• Synonyms: (S)-N-((S)-1-hydroxy-1,1-diphenylpropan-2-yl)-1-tritylazetidine-2-carboxamide
• CAS NO: 1551163-39-3
• Molecular Weight: 552.716
• Mol File: 1551163-39-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N-((S)-1-hydroxy-1,1-diphenylpropan-2-yl)-1-tritylazetidine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-((S)-1-hydroxy-1,1-diphenylpropan-2-yl)-1-tritylazetidine-2-carboxamide(1551163-39-3)
• EPA Substance Registry System: (S)-N-((S)-1-hydroxy-1,1-diphenylpropan-2-yl)-1-tritylazetidine-2-carboxamide(1551163-39-3)

Safety Data

• Hazardous Substances Data: 1551163-39-3(Hazardous Substances Data)

Upstream product

• 1551163-35-9 triethylamine (2S)-1-tritylazetidine-2-carboxylate 
• 78603-91-5 (S)-2-amino-1,1-diphenylpropan-1-ol 
• 1551163-29-1 methyl (2S)-1-tritylazetidine-2-carboxylate 
• 1551163-23-5 methyl (S)-N-trityl-2-amino-4-bromobutanoate 

Downstream Products

• 1551161-23-9 (S)-N-((2S)-1-hydroxy-1,1-diphenylpropan-2-yl)azetidine-2-carboxamide 

Relevant articles and documents

Enantiopure azetidine-2-carboxamides as organocatalysts for direct asymmetric aldol reactions in aqueous and organic media

A family of enantiopure azetidine-2-caboxamides was asymmetrically synthesized, and was examined as organocatalyst in direct aldol reactions. A well chosen chiral azetidine-2-caboxamide was found to smoothly catalyze the direct aldol reaction of various benzaldehydes with acetone in brine, and β-hydroxy ketones were produced with enantiomeric excess up to 96%. The reaction of benzaldehydes with cyclic ketones also led to the formation of anti-products in diastereomeric ratio up to 99:1 and enantiomeric excess up to 99%.