1551218-04-2

Basic information

• Product Name: C₂₁H₁₆BrN₅O₅
• Synonyms: C₂₁H₁₆BrN₅O₅
• CAS NO: 1551218-04-2
• Molecular Weight: 498.293
• Mol File: 1551218-04-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₆BrN₅O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₆BrN₅O₅(1551218-04-2)
• EPA Substance Registry System: C₂₁H₁₆BrN₅O₅(1551218-04-2)

Safety Data

• Hazardous Substances Data: 1551218-04-2(Hazardous Substances Data)

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 175203-55-1 4-prop-2-ynyloxybenzoic acid ethyl ester 
• 1505122-28-0 C₉H₄BrN₅O₂ 
• 723281-72-9 6-bromo-4-chloro-3-nitroquinoline 
• 853908-50-6 6-bromo-3-nitroquinolin-4-ol 
• 145369-94-4 6-bromoquinolin-4-ol 
• 1551219-53-4 C₁₃H₁₂BrNO₄ 
• 106-40-1 4-bromo-aniline 

Relevant articles and documents

Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents

In this research, a series of 4-(1,2,3-triazol-1-yl)coumarin conjugates were synthesized and their anticancer activities were evaluated in vitro against three human cancer cell lines, including human breast carcinoma MCF-7 cell, colon carcinoma SW480 cell and lung carcinoma A549 cell. To increase the biological potency, structural optimization campaign was conducted focusing on the C-4 position of 1,2,3-triazole and the C-6, C-7 positions of coumarin. In addition, to further evaluate the role of 1,2,3-triazole and coumarin for antiproliferative activity, 9 compounds possessing 4-(piperazin-1-yl)coumarin framework and 3 derivatives baring quinoline core were also synthesized. By MTT assay in vitro, most of the compounds display attractive antitumor activities, especially 23. Further flow cytometry assays demonstrate that compound 23 exerts the antiproliferative role through arresting G2/M cell-cycle and inducing apoptosis.