155131-43-4

Upstream product

• 134877-43-3 α-D-erythropentafuranose-2'-deoxy-2',2'-difluoro-3,5-dibenzoate-1-methanesulfonate 
• 64-19-7 acetic acid 
• 1173824-58-2 (2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate 

Relevant academic research and scientific papers

A nucleoside compound synthesis method (by machine translation)

The invention relates to a method for synthesis of nucleoside compound, in particular of formula I and II shown in the preparation method of the compound, in the formula I and II, R1 And R2 Respectively is independently an hydroxy protecting group, preferably benzoyl, trityl, disubstituted phenyl, ethyl or tertiary butyl dimethyl silyl group; R3 And R4 Is alkyl (preferably C1 - C10 Alkyl, more preferably methyl, ethyl) or halogen (such as F, Cl or Br); B is the following arbitrary group wherein R5 Hydrogen or alkyl (preferably C1 - C10 Alkyl, more preferably methyl); X is hydroxyl or amino; Y is sulfur. (by machine translation)

Novel nucleoside compounds and preparation method thereof

The invention relates to new nucleoside compounds of which the structure is disclosed as Formula I, wherein Y is cytosine, thymine, uracil or guanine group in which 2- or 6- oxygen is respectively substituted by selenium or sulfur. The structural formulae are respectively disclosed in the specification, wherein X is Se or S, and Z is Se, S or O. The novel gemcitabine analogs (such as monoatomic selenium substituted compounds) disclosed by the invention are hopeful to become drugs capable of substituting gemcitabine antineoplastic drugs.

METHOD OF TREATMENT OF TP53 WILD-TYPE TUMORS WITH 2',2'-DIFLUORO-5-AZA-2'-DEOXYCYTIDINE OR PRODRUGS THEREOF

This disclosure provides methods and strategies for inhibiting the growth of TP53 wild-type cancer cells, comprising contacting the cell with 2',2'-difluoro-5-aza-2'- deoxycytidine or a 2',2'-difluoro-5-aza-2'-deoxycytidine prodrug. Also provided are rela

SILYLATED PYRIMIDINE PRODRUGS AND METHODS OF THEIR USE

Silylated-pyrimidine prodrugs, compositions that include the silylated-pyrimidine prodrugs, methods for making the silylated-pyrimidine prodrugs and compositions, and methods for treating cancer using the silylated-pyrimidine prodrugs and compositions.

FLUORINATED PYRIMIDINE ANALOGS AND METHODS OF USE THEREOF

Fluorinated pyrimidine analog compounds, fluorinated pyrimidine analog compounds are including composition, fluorinated pyrimidine analogs method for preparing the compounds of, fluorinated pyrimidine analog compounds administering by inhibiting ladle sacrifice trans DNA, for treating solid tumors, method of treating multiple myeloma is provided. (by machine translation)

FLUORINATED PYRIMIDINE ANALOGS AND METHODS OF USE THEREOF

Fluorinated pyrimidine analog compounds, compositions that include the fluorinated pyrimidine analog compounds, methods for making the fluorinated pyrimidine analog compounds, and methods for inhibiting DNA methyltransferase, treating solid tumors, and treating hematologic cancers by administering the fluorinated pyrimidine analog compounds.