155154-69-1Relevant academic research and scientific papers
Asymmetric Synthesis of α′-Silylated α-Iodo Ketones via Iodination with Trifluoroiodomethane
Enders, Dieter,Klein, Daniela,Raabe, Gerhard,Runsink, Jan
, p. 1271 - 1272 (1997)
The diastereo- and enantioselective syntheses of various α′-t-butyldimethylsilyl-α-iodo ketones 4a-h is described. The carbon iodine bond formation is achieved using trifluoroiodomethane as the electrophilic iodination reagent. The iodo ketones 4 are obtained in good yields and with excellent diastereo- and enantiomeric excesses (de,ee ≥ 98%).
