Asymmetric Synthesis of α′-Silylated α-Iodo Ketones via Iodination with Trifluoroiodomethane

Article abstract of DOI:10.1055/s-1997-1013

The diastereo- and enantioselective syntheses of various α′-t-butyldimethylsilyl-α-iodo ketones 4a-h is described. The carbon iodine bond formation is achieved using trifluoroiodomethane as the electrophilic iodination reagent. The iodo ketones 4 are obtained in good yields and with excellent diastereo- and enantiomeric excesses (de,ee ≥ 98%).