155177-85-8Relevant academic research and scientific papers
A new strategy for stereoselective synthesis of sialic acid-containing glycopeptide fragment
Wang, Zhi-Guang,Zhang, Xu-Fang,Ito, Yukishige,Nakahara, Yoshiaki,Ogawa, Tomoya
, p. 1901 - 1908 (2007/10/03)
Sialic acid donor 5, which has a thiophenyl group as a stereocontrolling auxiliary and thiomethyl group as a leaving group was prepared and subjected to model glycosylation. Reactions with acceptor substrates 6, 7, and 8 gave coupled products 9b, 10b, and 11b, respectively, in a higher efficiency than previously observed for the bromide 1a. This reaction was further applied to the synthesis of protected glyco-amino acid fragment 12, that is strategically designed for the synthesis of sialic acid containing glycopeptides.
Stereoselective synthesis of a blood group A type glycopeptide present in human blood mucin
Macindoe,Ijima,Nakahara,Ogawa
, p. 227 - 257 (2007/10/02)
N,N-Dimethyl-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-(1 → 3)-O-[( α-L-fucopyranosyl)-(1 → 2)]-O-( β-D-galactopyranosyl)-(1 → 3)-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)(1 → 3)-L-serine, a core 1 glycotetraosyl peptide structure and a predominant
Synthesis of a glycotetraosyl serine, a partial structure of an ovarian cyst mucin glycoprotein of blood group A activity
Macindoe, Wallace M.,Iijima, Hiroyuki,Nakahara, Yoshiaki,Ogawa, Tomoya
, p. 1735 - 1738 (2007/10/02)
A glycotetraosyl serine containing blood group A determinant tetrasaccharide and its properly protected equivalent were synthesized in a regio- and stereocontrolled manner.
