155185-34-5Relevant academic research and scientific papers
Synthesis of Enantiomerically Pure (S)-(-)-Propranolol from Sorbitol
Veloo, Ronald A.,Koomen, Gerrit-Jan
, p. 2401 - 2404 (1993)
Synthesis of enantiomerically pure (S)-(-)-propanolol, the most active optical isomer of widely used β-Sympatholyticum, was achieved in high optical yield from starting sorbitol, an inexpensive and easily accessible carbohydrate.Via regioselective protection and coupling of α-naphthol, the key intermediate 5 was obtained.Deprotection of the intermediate acetals and successive oxidative degradation followed by some simple conversion steps lead to the formation of (S)-(-)-propranolol with high optically purity.Key Words: β-Sympatholyticum; Sorbitol; Asymmetric Synthesis; Acetals; Regioselective
