1552321-34-2Relevant academic research and scientific papers
Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors
Goto, Taiji,Shiina, Akiko,Murata, Takeshi,Tomii, Masato,Yamazaki, Takanori,Yoshida, Ken-Ichi,Yoshino, Toshiharu,Suzuki, Osamu,Sogawa, Yoshitaka,Mizukami, Kiyoshi,Takagi, Nana,Yoshitomi, Tomomi,Etori, Maki,Tsuchida, Hiroshi,Mikkaichi, Tsuyoshi,Nakao, Naoki,Takahashi, Mizuki,Takahashi, Hisashi,Sasaki, Shigeki
supporting information, p. 893 - 899 (2014/02/14)
A PDE4B subtype selective inhibitor is expected to have a wider therapeutic window than non-selective PDE4 inhibitors. In this Letter, two series of 7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives and 5,5-dioxo-7,8- dihydro-6H-thiopyrano[3,2-d]pyri
