87466-23-7

Basic information

• Product Name: 2,4-dichloro-7,8-dihydro-6H-Thiopyrano[3,2-d]pyrimidine
• Synonyms: 2,4-dichloro-7,8-dihydro-6H-Thiopyrano[3,2-d]pyrimidine;8-dihydro-6H-thiopyrano[3;2,4-Dichloro-6H,7H,8H-thiopyrano[3,2-d]pyrimidine
• CAS NO: 87466-23-7
• Molecular Formula: C₇H₆Cl₂N₂S
• Molecular Weight: 221.11
• EINECS: -0
• Mol File: 87466-23-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 108-110 °C
• Boiling Point: 346.666 °C at 760 mmHg
• Flash Point: 163.458 °C
• Appearance: /
• Density: 1.514 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.639
• PKA: -2.47±0.20(Predicted)
• CAS DataBase Reference: 2,4-dichloro-7,8-dihydro-6H-Thiopyrano[3,2-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-7,8-dihydro-6H-Thiopyrano[3,2-d]pyrimidine(87466-23-7)
• EPA Substance Registry System: 2,4-dichloro-7,8-dihydro-6H-Thiopyrano[3,2-d]pyrimidine(87466-23-7)

Safety Data

• Hazardous Substances Data: 87466-23-7(Hazardous Substances Data)

Usage

General Description

2,4-dichloro-7,8-dihydro-6H-Thiopyrano[3,2-d]pyrimidine is a chemical compound with the molecular formula C7H4Cl2N2S. It is a heterocyclic compound containing a thiopyran ring fused to a pyrimidine ring, with two chlorine atoms attached to the pyrimidine ring. 2,4-dichloro-7,8-dihydro-6H-Thiopyrano[3,2-d]pyrimidine has potential applications in the field of medicinal chemistry and drug development, as it may exhibit biological activity or pharmaceutical properties. Its synthesis and characterization are of interest to researchers in the scientific community for further exploration of its potential uses.

InChI:InChI=1/C7H6Cl2N2S/c8-6-5-4(2-1-3-12-5)10-7(9)11-6/h1-3H2

Upstream product

• 38555-41-8 methyl 3-oxo-2,3,4,5-tetrahydro-6H-thiopyran-2-carboxylate 
• 38555-40-7 methyl 4-{[2-(methyloxy)-2-oxoethyl]thio}butanoate 
• 87466-55-5 7,8-dihydro-4-hydroxy-2-methylthio-6H-thiopyrano<3,2-d>pyrimidine 
• 58509-73-2 ethyl 3-oxothiane-2-carboxylate 
• 87466-56-6 7,8-dihydro-2,4-dihydroxy-6H-thiopyrano<3,2-d>pyrimidine 
• 87466-56-6 7,8-dihydro-1H-thiopyrano[3,2-d]pyrimidine-2,4(3H,6H)-dione? 
• 157414-90-9 2-(ethylthio)-7,8-dihydro-3H-thiopyrano[3,2-d]pyrimidin-4(6H)-one 
• 63449-37-6 ethyl 4-<(2-ethoxy-2-oxoethyl)sulfanyl>butanoate 

Downstream Products

• 111896-64-1 4-Methoxy-2-(4-phenyl-piperazin-1-yl)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine 
• 111915-15-2 2-[4-(4-Diethylamino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-2-yl)-piperazin-1-yl]-1-phenyl-ethanol 
• 87466-66-8 4-(N-benzylpiperazino)-2-dimethylamino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine 
• 111915-05-0 2-[2-(4-Phenyl-piperazin-1-yl)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-ylamino]-ethanol 
• 87466-36-2 4-(4-Benzyl-piperazin-1-yl)-2-pyrrolidin-1-yl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine 
• 87466-51-1 2-<4-(2-chlorobenzyl)pyperazinyl>-7,8-dihydro-4-methylamino-6H-thiopyrano<3,2-d>pyrimidine 
• 87466-64-6 2-(N-benzylpiperazino)-4-morpholino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine 
• 111915-16-3 7,8-dihydro-2-<4-(2-hydroxy-2-phenylethyl)piperazinyl>-4-(1-morpholinyl)-6H-thiopyrano<3,2-d>pyrimidine 
• 1429638-98-1 (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-2-yl)phenyl)urea 
• 1552321-06-8 methyl 2-[4-[(2-chloro-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]acetate 
• 1552320-67-8 2-[4-[[2-(2-fluorophenyl)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl]amino]phenyl]acetic acid 
• 1552321-36-4 C₂₄H₂₂N₄O₂S 
• 1552321-37-5 C₂₄H₂₅N₃O₃S 
• 1552321-38-6 C₂₄H₂₅N₃O₃S 

Relevant articles and documents

Tetrahydrothiopyran and pyrimidine derivatives and its preparation method and application (by machine translation)

The invention discloses four diazanaphthylaone compound and its preparation method and application. The [...] and pyrimidines compound or its pharmaceutically acceptable salt or prodrug, has the following general formula I or II of the structure is shown, the invention also comprises four diazanaphthylaone compounds of preparation method and and containing one or more of such compounds in the preparation of the composition for the treatment and prevention of human immunodeficiency virus (HIV) application of the medicament. (by machine translation)

MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS

The invention relates to compounds of formula (I) wherein m, o, Ra, Rb, R1 and T1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments

Thiopyranopyrimidine compounds and acid addition salts thereof

Novel thiopyranopyrimidine compounds and the pharmaceutically acceptable acid addition salts thereof having excellent hypoglycemic activity, platelet aggregation inhibitory activity, antihistamine activity and anti-allergy activity useful for prevention and treatment of various disorders caused by diabetes, allergy and the like are disclosed.