155262-17-2Relevant academic research and scientific papers
3-Trifluoromethylthiophens from hexafluoroacetone
Burger, Klaus,Helmreich, Brigitte,Jendrewski, Oliver
, p. 13 - 14 (2007/10/02)
A one-pot procedure for the synthesis of 2-fluoro-3-trifluoromethyl-substituted thiophens 6 from 1-aryl-4,4-difluoro-3-trifluoromethylbut-3-en-1-one (3) and phosphorus pentasulfide is described.The fluorine atom at C-2 of compounds 6 undergoes nucleophili
Synthesis of 2-Fluoro-3-trifluoromethylthiophenes and 3-Trifluoromethylthiophenes from Hexafluoroacetone
Burger, Klaus,Helmreich, Brigitte,Popkova, Vera Ya.,German, Lev S.
, p. 819 - 832 (2007/10/02)
The transformation of bis(trifluoromethyl)-1-oxabuta-1,3-dienes (1) - available from hexafluoroacetone - into 2-fluoro-3-trifluoromethylthiophenes (9) via 4,4-difluoro-3-trifluoromethyl-3-buten-1-ones (5) is described.The fluorine atom at skeleton positio
