155265-57-9

Basic information

• Product Name: 2-Bromo-3-cyano-6-methylpyridine
• Synonyms: 2-Bromo-3-cyano-6-methylpyridine;2-Bromo-6-methyl-nicotinonitrile;2-bromo-6-methylpyridine-3-carbonitrile
• CAS NO: 155265-57-9
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.04
• Mol File: 155265-57-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 303.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.61±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.93±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-3-cyano-6-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-cyano-6-methylpyridine(155265-57-9)
• EPA Substance Registry System: 2-Bromo-3-cyano-6-methylpyridine(155265-57-9)

Safety Data

• Hazardous Substances Data: 155265-57-9(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-cyano-6-methylpyridine is a chemical compound with the molecular formula C7H5BrN2. It is a white to light yellow crystalline solid that is used in various chemical reactions and organic synthesis processes. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also known for its potent antibacterial and antifungal properties, and it is used in the development of new drug candidates. 2-Bromo-3-cyano-6-methylpyridine is considered to be a useful reagent in the field of medicinal chemistry and is utilized in the production of various biologically active compounds.

Upstream product

• 72918-03-7 2-methoxy-6-methylpyridine-3-carbonitrile 
• 4241-27-4 2-hydroxy-6-methylnicotinonitrile 
• 4241-27-4 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile 
• 1163297-78-6 C₈H₅F₃N₂O₃S 

Downstream Products

• 1365921-03-4 C₂₁H₁₇FN₄S 
• 1365920-98-4 C₂₂H₂₀N₄OS 
• 944503-59-7 4-[4-methyl-2-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol 
• 1365920-89-3 C₂₃H₂₁N₅OS 
• 944642-35-7 C₂₁H₁₈N₄S 
• 84647-20-1 2-amino-6-methylpyridine-3-carbonitrile 
• 944707-38-4 2-bromo-3-bromomethyl-6-methylpyridine 
• 853179-74-5 2-bromo-6-methylpyridine-3-carbaldehyde 

Relevant articles and documents

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives

The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d] pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays.

A new approach to the 1,10-phenanthroline core

A protocol for the synthesis of substituted 1,10-phenanthrolines is reported. The phenanthroline scaffold has been obtained constructing the central cycle starting from two pyridine rings. The method is hinged upon the intramolecular coupling of cis-1,2-di(2-bromo-3-pyridyl)ethenes that are in turn obtained from the Wittig reaction of 2-bromonicotinaldehydes with phosphonium salts prepared from 2-bromo-3-(bromomethyl)pyridines. Yields up to 75% have been obtained.

Process for producing halogenated heteroaryl compounds

PCT No. PCT/JP97/04508 Sec. 371 Date Jun. 8, 1999 Sec. 102(e) Date Jun. 8, 1999 PCT Filed Dec. 9, 1997 PCT Pub. No. WO98/25906 PCT Pub. Date Jun. 18, 1998The present invention relates to a process for producing a compound represented by the formula (II): wherein X is a halogen atom, each of A1, A2 and A3 are the same or different and are selected from a carbon atom or a nitrogen atom, provided that at least A1, A2, or A3 is a nitrogen atom. Each of R1, R2, R3 and R4 are the same or different and are selected from a hydrogen atom, a lower alkyl group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a halogen atom, and a nitro group. It is also provided that where R1 and R2 are adjacent to each other, R1 and R2 may be combined with each other to form a 5- or 6-membered ring which may carry on the ring thereof one substituent selected from the group consisting of a lower alkyl group, a nitrile group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a halogen atom, a nitro group, and an amino-(lower alkyl) group. The compound is prepared by reacting a compound represented by the formula (I): with a quaternary ammonium halide in the presence of phosphorus pentoxide.