155265-57-9

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Bromo-3-cyano-6-methylpyridine is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drug candidates. Its unique structure and properties make it a valuable component in the creation of innovative and effective medications.
Used in Agrochemical Production:
In the agrochemical industry, 2-Bromo-3-cyano-6-methylpyridine is utilized as a key intermediate in the synthesis of various agrochemicals. Its incorporation into these products helps to enhance their efficacy and performance in agricultural applications.
Used in Medicinal Chemistry Research:
As a useful reagent in medicinal chemistry, 2-Bromo-3-cyano-6-methylpyridine is employed in the research and development of biologically active compounds. Its versatility and reactivity make it an essential tool for chemists working on the design and synthesis of novel therapeutic agents.
Used in Antibacterial and Antifungal Agents Development:
Leveraging its potent antibacterial and antifungal properties, 2-Bromo-3-cyano-6-methylpyridine is used in the development of new agents to combat microbial infections. Its incorporation into these agents helps to improve their effectiveness and broaden the scope of treatment options available for various infections.

Upstream product

• 4241-27-4 2-hydroxy-6-methylnicotinonitrile 
• 1163297-78-6 C₈H₅F₃N₂O₃S 
• 4241-27-4 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile 
• 72918-03-7 2-methoxy-6-methylpyridine-3-carbonitrile 

Downstream Products

• 1365921-03-4 C₂₁H₁₇FN₄S 
• 1365920-98-4 C₂₂H₂₀N₄OS 
• 944503-59-7 4-[4-methyl-2-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol 
• 1365920-89-3 C₂₃H₂₁N₅OS 
• 944642-35-7 C₂₁H₁₈N₄S 
• 84647-20-1 2-amino-6-methylpyridine-3-carbonitrile 
• 944707-38-4 2-bromo-3-bromomethyl-6-methylpyridine 
• 853179-74-5 2-bromo-6-methylpyridine-3-carbaldehyde 

Relevant academic research and scientific papers

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives

The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d] pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays.

One-pot iodination of hydroxypyridines

(Chemical Equation Presented) A one-pot, high-yielding iodination of hydroxypyridines and hydroxyquinolines is described. The iodination proceeds under mild conditions, and the products are obtained in high yield without the need for chromatographic purif

A new approach to the 1,10-phenanthroline core

A protocol for the synthesis of substituted 1,10-phenanthrolines is reported. The phenanthroline scaffold has been obtained constructing the central cycle starting from two pyridine rings. The method is hinged upon the intramolecular coupling of cis-1,2-di(2-bromo-3-pyridyl)ethenes that are in turn obtained from the Wittig reaction of 2-bromonicotinaldehydes with phosphonium salts prepared from 2-bromo-3-(bromomethyl)pyridines. Yields up to 75% have been obtained.

A facile bromination of hydroxyheteroarenes

Bromination of hydroxyheteroarenes using P2O5/Bu4NBr proceeds under mild conditions to afford high yields of various bromoheteroarenes. This procedure is successfully applied to large-scale syntheses of bromoheteroarenes.

Process for producing halogenated heteroaryl compounds

PCT No. PCT/JP97/04508 Sec. 371 Date Jun. 8, 1999 Sec. 102(e) Date Jun. 8, 1999 PCT Filed Dec. 9, 1997 PCT Pub. No. WO98/25906 PCT Pub. Date Jun. 18, 1998The present invention relates to a process for producing a compound represented by the formula (II): wherein X is a halogen atom, each of A1, A2 and A3 are the same or different and are selected from a carbon atom or a nitrogen atom, provided that at least A1, A2, or A3 is a nitrogen atom. Each of R1, R2, R3 and R4 are the same or different and are selected from a hydrogen atom, a lower alkyl group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a halogen atom, and a nitro group. It is also provided that where R1 and R2 are adjacent to each other, R1 and R2 may be combined with each other to form a 5- or 6-membered ring which may carry on the ring thereof one substituent selected from the group consisting of a lower alkyl group, a nitrile group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a halogen atom, a nitro group, and an amino-(lower alkyl) group. The compound is prepared by reacting a compound represented by the formula (I): with a quaternary ammonium halide in the presence of phosphorus pentoxide.

DIRECT SUBSTITUTION OF A METHOXY GROUP BY BROMINE IN 2-METHOXYPYRIDINE-3-CARBONITRILES: A SYNTHESIS OF 2-BROMOPYRIDINE-3-CARBONITRILES

The treatment of a wide variety of 2-methoxypyridine-3-carbonitriles with phosphorus oxytribromide in the presence of pyridinium hydrobromide and phosphoric acid yields directly the corresponding pyridine system in which the methoxy group has been substit