72918-03-7

Usage

Uses

Used in Pharmaceutical Industry:
2-methoxy-6-methylnicotinonitrile (SALTDATA: FREE) is used as a building block in the synthesis of various drugs and pharmaceutical products. Its unique chemical structure and properties make it a valuable component in the development of new medications and therapies.

Upstream product

• 67-56-1 methanol 
• 78-94-4 methyl vinyl ketone 
• 109-77-3 malononitrile 
• 124-41-4 sodium methylate 

Downstream Products

• 72918-10-6 2-Methoxy-6-methylpyridine-3-carboxylic acid 
• 72918-15-1 6-<(4'-Phenylthio)-(E)-styryl>-2-pyridone-3-carboxylic acid 
• 73035-75-3 n-Hexadecyl 6-<(4'-phenylthio)-(E)-styryl>-2-pyridone-3-carboxylate 
• 864779-08-8 6-(bromomethyl)-2-methoxynicotinonitrile 
• 85606-05-9 N-{(2-Methoxy-6-methyl-pyridin-3-yl)-[(Z)-4-methoxy-phenylimino]-methyl}-oxalamic acid ethyl ester 
• 85606-06-0 N-[[(Z)-4-Chloro-phenylimino]-(2-methoxy-6-methyl-pyridin-3-yl)-methyl]-oxalamic acid ethyl ester 
• 85606-08-2 N-Phenyl-N'-(N''-n-butyloxamoyl)-6-methyl-2-methoxynicotinamidine 
• 85606-04-8 N-{(2-Methoxy-6-methyl-pyridin-3-yl)-[(Z)-p-tolylimino]-methyl}-oxalamic acid ethyl ester 
• 85606-03-7 N-{(2-Methoxy-6-methyl-pyridin-3-yl)-[(Z)-phenylimino]-methyl}-oxalamic acid ethyl ester 
• 85606-07-1 N-Phenyl-N'-oxamoyl-2-methoxy-6-methylnicotinamidine 
• 155265-57-9 2-bromo-6-methylpyridine-3-carbonitrile 
• 72918-04-8 2-Methoxy-6-methylpyridine-3-carboxaldehyde 
• 85605-98-7 2-Methoxy-6-methyl-N-phenyl-nicotinamidine 
• 85606-00-4 2-Methoxy-N-(4-methoxy-phenyl)-6-methyl-nicotinamidine 

Relevant academic research and scientific papers

SYNTHESIS OF 4-AMINO-8-CYANOQUINAZOLINES FROM ENONES AND ENALS

The treatment in a sodium methoxide/methanol solution of α,β-unsaturated enones or aldehydes with propanedinitrile in a 1:2 molar ratio led to 2-aminobenzene-1,3-dicarbonitriles.These compounds afforded 4-amino-8-cyanoquinazolines by reaction with formamide or guanidine.

A Simple Synthesis of 2-Methoxypyridine-3-carbonitriles

The condensation of propanedinitrile with several enals or enones in a methanol-sodium methoxide system provides a one-step route to 2-methoxypyridine-3-carbonitriles.Together with these compounds substituted 2-aminobenzene-1,3-dicarbonitriles, were obtained as by-products.