155268-28-3

Upstream product

• 52421-93-9 (2Z)-3-methyl-2-penten-4-ynal 
• 536-74-3 phenylacetylene 
• 6153-05-5 (Z)-3-methylpent-2-en-4-ynol 

Downstream Products

• 1261168-00-6 4,5-dimethyl-1-(phenylethynyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid dimethyl ester 
• 1261168-01-7 4,5-dimethyl-1-(phenylethynyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of Furans by Cyclization of 2-En-4-yn-1-ols in the Presence of Ruthenium and Palladium Catalysts

Substituted furans have been synthesized in the presence of ruthenium catalysts under neutral and mild conditions via cyclization of primary and secondary enynols of type (Z)-HCC-C(Me)=CH-CH(R)OH containing a terminal triple bond.The intramolecular addition of the hydroxy group to the triple bond of internal (Z)-enynols is also possible upon palladium catalysis.

Novel ruthenium-catalysed synthesis of furan derivatives via intramolecular cyclization of hydroxy enynes

Furans containing a functional group at C(5) are obtained under neutral conditions by selective cyclization of (Z)-pent-2-en-4-yn-1-ols in the presence of RuCl2(PPh3)(p-cymene) as catalyst precursor.