6153-05-5Relevant articles and documents
Synthetic study of an intermediate towards paracentrone
Kaneyama, Taiki,Fujimaru, Kazumi,Takemura, Mami,Hasegawa, Kizuku,Hamada, Masahiro,Kishimoto, Takao,Urabe, Daisuke,Nakajima, Noriyuki
, p. 281 - 294 (2019/08/01)
Paracentrone (1), the second naturally occurring C31-methyl ketone apocarotenoid from fucoxanthin (2), was first isolated from the sea urchin Paracentrotus lividus. In this study, we focused on this carotenoid metabolite and report on a synthetic approach towards (3E)-(5R)-[(2R,4S)-2-hydroxy-4-(tert-butyldimethylsilyl)oxy-2,6,6-trimethylcyclohexylidene]-1-iodo-4-methyl-1,3, 5-hexatriene (5), a synthetic intermediate towards 1. This was obtained from epoxy acetylene (11) via (2E)-(4R)-[(2R,4S)-2-hydroxy-4-(tert-butyldimethyl-silyl)oxy-2,6,6-trimethylcyclohexylidene]-3-methylpenta-2,4-dien-1-ol (7).
A method of product yield allylol cis
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Paragraph 0030-0032, (2017/03/17)
The invention relates to a method for improving the yield of an allyl alcohol maleinoid form product, the formula (1) are isomerized into a mixture of the formula (2) and the formula (3), the formula (1), the formula (2) and the formula (3) are selected from alkyl, aryl and alkaryl, R2 is selected from H, alkyl and aryl, in a solvent and with the existence of a heterogeeous acid catalyst, the formula (1) is subjected to reaction, the solvent is water or a multiphase solvent system which comprises an aqueous phase and an organic solvent phase, and the organic solvent phase comprises an organic solvent which is selected from ethers, ketone or saturated fat hydrocarbon or a mixture of the same and is unmixed with water, the formula (1) is subjected to allylic rearrangement reaction, and a certain proportion of formula (3) is added into the allylic rearrangement reaction system of the formula (1); the gaseous phase interior label content of the formula (3) is greater than 95%. According to the invention, the forming of the product maleinoid form (2) is facilitated, the proportion of the maleinoid form (2) to the transform (3) is enhanced, and the yield of the maleinoid form (2) can be improved by about 13% compared with an original system.
ORTHO-FLUORO SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES
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Page/Page column 46-47, (2012/10/18)
There is provided novel fluoro-substituted compounds capable of modulating the G- protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type II diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.