1552723-48-4

Basic information

• Product Name: C₁₄H₁₅ClN₂O₂
• Synonyms: C₁₄H₁₅ClN₂O₂
• CAS NO: 1552723-48-4
• Molecular Weight: 278.738
• Mol File: 1552723-48-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₅ClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₅ClN₂O₂(1552723-48-4)
• EPA Substance Registry System: C₁₄H₁₅ClN₂O₂(1552723-48-4)

Safety Data

• Hazardous Substances Data: 1552723-48-4(Hazardous Substances Data)

Upstream product

• 93-02-7 2,5-dimethoxybenzaldehyde 
• 462-08-8 pyridin-3-ylamine 
• 56700-70-0 3-(tert-butoxycarbonylamino)pyridine 
• 3840-27-5 2,5-dimethoxybenzyl chloride 
• 1565870-89-4 C₁₉H₂₃ClN₂O₄ 
• 1068976-14-6 tert-butyl (4-chloropyridin-3-yl)carbamate 

Downstream Products

• 1565870-67-8 3-(2,5-dimethoxybenzyl)-3H-imidazo[4,5-c]pyridine 

Relevant articles and documents

Synthesis of N-Substituted 3-Amino-4-halopyridines: A Sequential Boc-Removal/Reductive Amination Mediated by Br?nsted and Lewis Acids

N-Substituted 3-amino-4-halopyridines are valuable synthetic intermediates, as they readily provide access to imidazopyridines and similar heterocyclic systems. The direct synthesis of N-substituted 3-amino-4-halopyridines is problematic, as reductive aminations and base-promoted alkylations are difficult in these systems. A high yielding deprotection/alkylation protocol mediated by trifluoroacetic acid and trimethylsilyl trifluoromethanesulfonate is described, providing access to a wide scope of N-substituted 3-amino-4-halopyridines. This protocol furnishes many reaction products in high purity without chromatography. Similar reductive amination conditions were also established for deactivated anilines.