155301-29-4Relevant academic research and scientific papers
Synthesis of 3'-Fluoromethylthio-, 3'-Fluoromethylsulfinyl- and 3'-Fluoromethylsulfonyl-substituted 3'-Deoxythymidine
Herdewijn, Piet,Bruyn, Andre De,Wigerinck, Piet,Hendrix, Chris,Kerremans, Luk,et al.
, p. 249 - 256 (2007/10/02)
3'-Deoxy-3'-(fluoromethylthio)thymidine 2 is synthesized from 5'-O-benzoyl-3'-deoxy-3'-(methylsulfinyl)thymidine 9 by using DAST. 5'-O-Benzoyl-3'-deoxy-3'-(fluoromethylthio)thymidine is used as starting material for the synthesis of the sulfoxide 3 and the sulfone 4.Both sulfoxides 3A and 3B show a C3'-endo sugar conformation.
