155304-07-7Relevant academic research and scientific papers
Synthetic applications of the nickel-catalyzed cyclization of alkynes combined with addition reactions in a domino process
Durandetti, Muriel,Hardou, Lucie,Lhermet, Rudy,Rouen, Mathieu,Maddaluno, Jacques
, p. 12773 - 12783 (2011/12/04)
Carbonickelations of alkynes and functionalization of the resulting vinylnickel moiety have been performed efficiently in a nickel-catalyzed domino cyclization-condensation process. This reaction, which does not require the preparation of any other organometallic reagent, proceeds only by exo-dig cyclization. This convenient and mild method constitutes a one-pot synthesis of substituted dihydrobenzofurans, chromans, isochromans, indoles, or indanes. Theses valuable products are generally obtained in good yields and high stereoselectivity. They are shown to be useful synthons for rapid access to functionalized polycyclic skeletons. Yes nickel can! Carbonickelation of alkynes and functionalization of the resulting vinylnickel moiety occurs efficiently. Overall, a domino cyclization-condensation process propagated by substoichiometric nickel catalysis takes place (see scheme). This one-pot synthesis provides substituted polyheterocyclic compounds in good yields and high stereoselectivity.
Chromium(II)-Mediated Nickel(II)-Catalysed Cyclisations of (Iodoaryl)-Substituted Alkynes and Alkynals
Hodgson, David M.,Wells, Christopher
, p. 1601 - 1604 (2007/10/02)
The Chromium(II)-mediated Nickel(II)-catalysed cyclisations of (iodoaryl)-substituted alkynes 1, 2 and 7 and (iodoaryl)-substituted alkynals 9 and 10 to give the products 5, 6, 8, 11 and 12 respectively is described.
