1188474-17-0Relevant articles and documents
Palladium-catalyzed carbene/alkyne metathesis with enynones as carbene precursors: Synthesis of fused polyheterocycles
Zheng, Yang,Bao, Ming,Yao, Ruwei,Qiu, Lihua,Xu, Xinfang
, p. 350 - 353 (2018)
An unprecedented palladium-catalyzed novel carbene/alkyne metathesis cascade reaction of alkyne-tethered enynones is described. This reaction affords fused polyheterocycles in moderate to good yields. The transformation begins with Pd-catalyzed 5-exo-dig cyclization of the enynone to form the donor/donor metal carbene, which then undergoes metathesis with the alkyne followed by electrophilic aromatic substitution.
Synthesis of fused dibenzofuran derivatives via palladium-catalyzed domino C-C bond formation and iron-catalyzed cycloisomerization/aromatization
Paul, Kartick,Jalal, Swapnadeep,Kundal, Sandip,Jana, Umasish
, p. 1164 - 1174 (2016/02/19)
A range of tetracyclic dibenzofuran derivatives bearing a variety of functional groups was readily synthesized via a two-stage domino strategy starting from propargyl ethers of 2-halo phenol derivatives. The first stage in the strategy involves Pd(0)-catalyzed domino intramolecular carbopalladation/Suzuki coupling via 5-exo-dig cyclization onto the alkyne, leading to 3-methylene-2,3-dihydrobenzofuran derivatives. In the second stage of the domino strategy, an iron(III)-catalyzed cycloisomerization and aromatization reaction produces tetracyclic benzofuran derivatives. This two-step sequence provides efficient access to diversely substituted polycyclic dibenzofuran derivatives in high yields and in an atom-efficient and environmentally friendly manner. Moreover, this strategy was also successfully used for the synthesis of a naturally occurring tetracyclic dibenzofuran, β-brazan.
Heterocyclization by catalytic carbonickelation of alkynes: A domino sequence involving vinylnickels
Durandetti, Muriel,Hardou, Lucie,Clement, Marie,Maddaluno, Jacques
supporting information; experimental part, p. 4753 - 4755 (2010/01/15)
Reaction of Ni(0) in the presence of iodoarylethers 1 leads, after syn intramolecular carbonickelation of the triple bond, to nucleophilic vinylnickels which can be trapped, in a tandem process, by various electrophiles introduced at the onset of the reac
