155370-83-5

Basic information

• Product Name: 7,13-Bis(triethylsilyl)-10-deoxybaccatin
• Synonyms: 7,13-Bis(triethylsilyl)-10-deoxybaccatin
• CAS NO: 155370-83-5
• Molecular Weight: 757.125
• Mol File: 155370-83-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7,13-Bis(triethylsilyl)-10-deoxybaccatin(CAS DataBase Reference)
• NIST Chemistry Reference: 7,13-Bis(triethylsilyl)-10-deoxybaccatin(155370-83-5)
• EPA Substance Registry System: 7,13-Bis(triethylsilyl)-10-deoxybaccatin(155370-83-5)

Safety Data

• Hazardous Substances Data: 155370-83-5(Hazardous Substances Data)

Upstream product

• 149140-53-4 C₄₂H₄₉F₅O₁₁SSi 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 
• 994-30-9 triethylsilyl chloride 
• 32981-86-5 10-deacetylbaccatin III 
• 149140-51-2 10-Deacetoxy-7-(triethylsilyl)baccatin III 

Relevant articles and documents

The Chemistry of Taxanes: Skeletal Rearrangements of Baccatin Derivatives via Radical Intermediates

In the course of a synthetic program aimed at systematic defunctionalization of the taxol core for structure activity studies, a number of radical-based deoxygenation reactions were carried out on baccatin III derivatives.In this connection, we have discovered that formation of radicals at positions C-1, C-2, and C-7 in the taxane core of baccatin III results in a number of skeletal rearrangement cascades.Furthermore, the exact composition of the product mixture depends on the specific tin (or silicon) hydride used for the reduction.In the case of C-2 and C-7-derived radicals, direct quenching with tin hydrides without rearrangement was possible under some conditions.However, we were unable to find conditions to quench the C-1 radical, since rearrangement pathways always predominate in this case.