155388-97-9

Upstream product

• 96-97-9 5-nitrosalicylic acid 
• 3360-41-6 4-phenyl-butan-1-ol 
• 155388-74-2 2-Hydroxy-5-nitro-benzoic acid 4-phenyl-butyl ester 

Relevant academic research and scientific papers

Leukotriene A4 hydrolase and cyclooxygense double target inhibitors and use thereof

The invention discloses a double-target inhibitor for leukotriene A4 hydrolase and cyclooxygenase as well as a purpose of the double-target inhibitor. The double-target inhibitor is a compound shown in a general formula (I), wherein X1 and X2 are respectively and independently separated into hydrogen, halogen, alkyl or alkoxy; Y represents hydrogen, hydroxyl, halogen or alkyl; Z represents substituent groups at the fourth position and/or the fifth position of a benzoyl core benzene ring, and respectively represents hydrogen, halogen, amino, alkyl acylamino, alkyl substituted amino, trifluoromethyl or carboxyl alkyl acylamino; n is 2 to 4. The compound can be used for preparing medicine for treating, preventing or inhibiting inflammation such as arthritis and rheumatoid arthritis.

Structure-activity relationships in a series of 5-[(2,5- dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: Importance of additional hydrophobic aromatic interactions

Potent inhibitors of EGF-dependent protein tyrosine kinase (PTK) activity were synthesized in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylates. Several of these compounds inhibited EGF-dependent DNA synthesis in ER 22 cells with IC50 1 μ