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3360-41-6

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3360-41-6 Usage

Chemical Properties

colourless liquid

Uses

Different sources of media describe the Uses of 3360-41-6 differently. You can refer to the following data:
1. 4-Phenyl-1-butanol is used as a reagent in the synthesis of substituted pyrrolidine-2-carboxylic acids which are used in the treatment of AT2 receptor function associated diseases.
2. 4-Phenyl-1-butanol was used in synthesis of NK105, a paclitaxel-incorporating micellar nanoparticle formulation.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 31, p. 2607, 1983 DOI: 10.1248/cpb.31.2607Journal of the American Chemical Society, 73, p. 124, 1951 DOI: 10.1021/ja01145a045

General Description

4-Phenyl-1-butanol is oxidized by ceric ammonium nitrate in acetonitrile to afford 2-phenyltetrahydrofuran. It undergoes cyclization in presence of phosphoric acid at high temperature to yield tetralin.

Check Digit Verification of cas no

The CAS Registry Mumber 3360-41-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,6 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3360-41:
(6*3)+(5*3)+(4*6)+(3*0)+(2*4)+(1*1)=66
66 % 10 = 6
So 3360-41-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H14O/c11-9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7,11H,4-5,8-9H2

3360-41-6 Well-known Company Product Price

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  • Alfa Aesar

  • (A13433)  4-Phenyl-1-butanol, 97%   

  • 3360-41-6

  • 10g

  • 738.0CNY

  • Detail
  • Alfa Aesar

  • (A13433)  4-Phenyl-1-butanol, 97%   

  • 3360-41-6

  • 50g

  • 1923.0CNY

  • Detail
  • Alfa Aesar

  • (A13433)  4-Phenyl-1-butanol, 97%   

  • 3360-41-6

  • 250g

  • 8167.0CNY

  • Detail

3360-41-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-phenylbutan-1-ol

1.2 Other means of identification

Product number -
Other names Phenylbutyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3360-41-6 SDS

3360-41-6Synthetic route

4-phenylbutyl acetate
7492-40-2

4-phenylbutyl acetate

A

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

B

phenol
108-95-2

phenol

Conditions
ConditionsYield
With phosphate buffer; Phenyl acetate In diethyl ether for 2.75h; Ambient temperature; pig liver acetone powder;A 5%
B 100%
4-Phenylbutyric acid
1821-12-1

4-Phenylbutyric acid

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
Stage #1: 4-Phenylbutyric acid With sodium tetrahydroborate In tetrahydrofuran at 60℃; for 0.25h;
Stage #2: With iodine In tetrahydrofuran for 5h; Reagent/catalyst;
99%
Stage #1: 4-Phenylbutyric acid With sodium tetrahydroborate In tetrahydrofuran at 60℃; for 0.25h;
Stage #2: With iodine In tetrahydrofuran for 5h;
98.4%
With C25H42N6Rh(1+)*CF3O3S(1-); phenylsilane In tetrahydrofuran at 30℃; for 20h; Inert atmosphere;96%
2-pyridyldimethyl(4-phenylbutyl)silane

2-pyridyldimethyl(4-phenylbutyl)silane

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol at 50℃; Oxidation;98%
With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol at 50℃; for 6h;96%
tert-butyldimethylsilyl 4-phenylbutyl ether
72064-43-8

tert-butyldimethylsilyl 4-phenylbutyl ether

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol; dichloromethane at 20 - 25℃; for 0.333333h; Flow reactor;98%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;249 mg
4-phenylbutyl acetate
7492-40-2

4-phenylbutyl acetate

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With ytterbium(III) triflate In isopropyl alcohol for 12h; Deacetylation; Heating;95%
With 2,2-dibutyl-1,3,2-dioxastannane; cesium fluoride In N,N-dimethyl-formamide at 20℃; for 1h;95%
1-Chloro-4-phenylbutane
4830-93-7

1-Chloro-4-phenylbutane

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With iron(III) sulfate; water In toluene at 110℃; for 1h; Ionic liquid;95%
4-Phenyl-1-butyne
16520-62-0

4-Phenyl-1-butyne

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); Ru(Cp)(PPh2PytBu)2(MeCN)PF6; water In isopropyl alcohol at 70℃; for 48h; Inert atmosphere; regioselective reaction;95%
With [2,2]bipyridinyl; formic acid; (η5-cyclopentadienyl) (η6-naphthalene)ruthenium hexafluorophosphate; water In tetrahydrofuran at 55℃; for 48h;88%
With formic acid; F6P(1-)*C16H22N3Ru(1+); water In 1-methyl-pyrrolidin-2-one at 25℃; for 48h; Inert atmosphere; Sealed tube;87%
C13H19NOS2

C13H19NOS2

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With thiophenol; 1,1'-azobis(1-cyanocyclohexanenitrile) In chlorobenzene at 110℃; for 12h;94%
4-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butane
167693-07-4

4-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butane

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
Stage #1: 4-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butane With sodium perborate tetrahydrate; water In tetrahydrofuran at 40℃; for 0.0166667h; Schlenk technique; Flow reactor;
Stage #2: With sodium thiosulfate In tetrahydrofuran Schlenk technique; Flow reactor;
92%
With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran at 55℃; for 3h;80%
2-(4-phenyl-butoxy)-tetrahydro-pyran
333742-34-0

2-(4-phenyl-butoxy)-tetrahydro-pyran

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With indium(III) triflate In methanol; water at 0 - 20℃; for 6h;92%
4-phenylbutyl 1-trifluoromethanesulfonate

4-phenylbutyl 1-trifluoromethanesulfonate

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With N1,N1,N12,N12-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a:2,1'-c][1,4]diazepine-2,12-diamine In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;91%
C24H22O4

C24H22O4

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 60℃; for 4h;91%
(cp)Fe(CO)2(COCH2CH2Ph)

(cp)Fe(CO)2(COCH2CH2Ph)

(C5H5)Fe(CO)2((CH2)3(C6H5))

(C5H5)Fe(CO)2((CH2)3(C6H5))

trimethylstannane
1631-73-8

trimethylstannane

A

3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

(C5H5)Fe(H)(CO)(Sn(CH3)3)2

(C5H5)Fe(H)(CO)(Sn(CH3)3)2

C

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

D

3-benzyl propionaldehyde
18328-11-5

3-benzyl propionaldehyde

Conditions
ConditionsYield
In benzene under Ar; 80°C, 5 h;A <1
B 42%
C 7%
D 88%
4-(4-bromophenyl)butanoic acid
35656-89-4

4-(4-bromophenyl)butanoic acid

A

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

B

4-(p-bromophenyl)-butan-1-ol
75906-36-4

4-(p-bromophenyl)-butan-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 25℃; for 2.25h;A 10%
B 88%
1-methoxy-4-((4-phenylbutoxy)methyl)benzene

1-methoxy-4-((4-phenylbutoxy)methyl)benzene

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With oxalyl dichloride In 1,2-dichloro-ethane at 20℃; for 2.66667h;87%
(4-(benzyloxy)butyl)benzene
101747-16-4

(4-(benzyloxy)butyl)benzene

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With aluminium trichloride; N,N-dimethyl-aniline In dichloromethane for 0.5h; Ambient temperature;86%
Stage #1: (4-(benzyloxy)butyl)benzene With Bromotrichloromethane; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In dichloromethane at 20℃; for 12h; Inert atmosphere; Irradiation;
Stage #2: With methanol In dichloromethane Inert atmosphere;
67%
ethyl 4-phenylbutyrate
10031-93-3

ethyl 4-phenylbutyrate

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
Stage #1: ethyl 4-phenylbutyrate With polyethylsiloxane; LiTi(OPr-i)4 at 100℃; for 24h;
Stage #2: With sodium hydroxide In tetrahydrofuran for 3h; Heating;
85%
With lithium aluminium tetrahydride; diethyl ether
With ethanol; sodium
With sodium hydroxide In tetrahydrofuran; water
2-benzylsulfanyl-4-phenyl-butyraldehyde
273214-46-3

2-benzylsulfanyl-4-phenyl-butyraldehyde

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); n-Bu3SH In benzene for 1.5h; Reduction; Heating;85%
α-(trichloromethyl)benzenepropanol
82772-38-1

α-(trichloromethyl)benzenepropanol

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With lithium borohydride; sodium hydroxide In isopropyl alcohol Temperature; Jocic Reaction; Heating; Inert atmosphere;85%
4-chlorobutyl benzoate
946-02-1

4-chlorobutyl benzoate

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
Stage #1: 4-chlorobutyl benzoate With aluminum (III) chloride In benzene at -5℃; for 2h; Cooling with ice; Large scale;
Stage #2: With methanol; water; sodium hydroxide Reflux; Large scale;
83%
tetrahydrofuran
109-99-9

tetrahydrofuran

phenylmagnesium chloride
100-59-4

phenylmagnesium chloride

A

(3E)-4-phenyl-3-buten-1-ol
937-58-6, 20047-19-2, 770-36-5

(3E)-4-phenyl-3-buten-1-ol

B

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
Stage #1: tetrahydrofuran; phenylmagnesium chloride With lithium chloride; manganese(ll) chloride at 0℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: With iodobenzene for 1h; Inert atmosphere; Schlenk technique;
Stage #3: With water Inert atmosphere; Schlenk technique;
A 7%
B 81%
4-phenylbutan-1-yl diphenylmethylsilyl ether

4-phenylbutan-1-yl diphenylmethylsilyl ether

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With potassium (4-methylphenyl)trifluoroborate In dimethyl sulfoxide at 37℃; for 10h; Inert atmosphere;80%
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

pyrocatecholborane

pyrocatecholborane

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
Stage #1: 3-phenyl-propionaldehyde; diazomethyl-trimethyl-silane With triphenylphosphine; isopropyl alcohol; Wilkinson's catalyst In tetrahydrofuran at 20℃; for 2h;
Stage #2: pyrocatecholborane In 1,4-dioxane at 20℃; for 2h;
Stage #3: With sodium hydroxide; dihydrogen peroxide In 1,4-dioxane at 20℃; for 3h;
79%
1,2-Epoxy-4-phenylbutane
1126-76-7

1,2-Epoxy-4-phenylbutane

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With bis(cyclopentadienyl)titanium dichloride; manganese; water In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;79%
With bis(cyclopentadienyl)titanium dichloride; manganese; water In tetrahydrofuran for 6h;78%
(4-(tert-butoxy)butyl)benzene
135886-84-9

(4-(tert-butoxy)butyl)benzene

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With zinc dibromide In dichloromethane for 24h; dealkylation;78%
2,3-(dibenzylthio)-4-phenylbutanal

2,3-(dibenzylthio)-4-phenylbutanal

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); n-Bu3SH In benzene Reduction;77%
4-phenyl-1-butylamine
13214-66-9

4-phenyl-1-butylamine

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With potassium hydroxide In diethylene glycol at 210℃; for 12h; Product distribution; Further Variations:; Reaction partners; Solvents;76%
With potassium hydroxide In diethylene glycol at 210℃; Substitution;59%
1-phenyl-butane-1,4-diol
4850-50-4

1-phenyl-butane-1,4-diol

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
With indium(III) chloride; diphenylsilyl chloride In 1,2-dichloro-ethane at 80℃; for 3h;76%
carbon monoxide
201230-82-2

carbon monoxide

1-iodo-3-phenylpropan
4119-41-9

1-iodo-3-phenylpropan

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

Conditions
ConditionsYield
Stage #1: carbon monoxide; 1-iodo-3-phenylpropan With diethoxymethylane; [CuCl(IPrMe)]; lithium methanolate In tetrahydrofuran at 60℃; under 2280.15 Torr; for 16h; Sealed tube;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran; diethyl ether at 20℃; for 2h; Catalytic behavior; Reagent/catalyst; Pressure;
75%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

1-Chloro-4-phenylbutane
4830-93-7

1-Chloro-4-phenylbutane

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; 1,2-dichloro-ethane; triphenylphosphine at 120℃; for 0.5h; Sealed tube; Inert atmosphere;100%
With oxalyl dichloride In dichloromethane at 20℃; Appel Halogenation; Reflux;98%
With thionyl chloride at 20℃; for 1.5h; Cooling with ice; Large scale;94%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

3-benzyl propionaldehyde
18328-11-5

3-benzyl propionaldehyde

Conditions
ConditionsYield
With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere;100%
With pyridinium chlorochromate In dichloromethane at 20℃; for 3h;100%
With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -55℃; for 0.25h; Oxidation; Swern oxidation;99%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

4-phenylbutyl 4-nitrobenzoate

4-phenylbutyl 4-nitrobenzoate

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 25℃; for 16h; Mitsunobu reaction;100%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

4-(1,4-cyclohexadien-1-yl)-1-butanol

4-(1,4-cyclohexadien-1-yl)-1-butanol

Conditions
ConditionsYield
With ammonia; sodium In ethanol at -78 - 20℃; Birch reduction;100%
With lithium In ethanol; ammonia at -78 - 20℃; Birch Reduction; liquid NH3;98.3%
carbon tetrabromide
558-13-4

carbon tetrabromide

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

1-Bromo-4-phenylbutane
13633-25-5

1-Bromo-4-phenylbutane

Conditions
ConditionsYield
With triphenylphosphine In dichloromethane; hexane-diethyl ether100%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

1-(4-azidobutyl)benzene
7332-01-6

1-(4-azidobutyl)benzene

Conditions
ConditionsYield
Stage #1: 4-phenyl-butan-1-ol With 1,2-Diiodoethane; N,N-dimethyl-formamide; triphenylphosphine at 20℃; for 0.0166667h; Sealed tube; Inert atmosphere;
Stage #2: With sodium azide at 20℃; Sealed tube; Inert atmosphere;
100%
Stage #1: 4-phenyl-butan-1-ol With dmap; triethylamine; p-toluenesulfonyl chloride In dichloromethane at 0 - 20℃;
Stage #2: With sodium azide In N,N-dimethyl-formamide at 20℃;
55%
With sodium azide; methanesulfonyl chloride
Multi-step reaction with 2 steps
1: triphenylphosphine; iodine; 1H-imidazole / 5.25 h / 0 - 20 °C
2: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C
View Scheme
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

4-trifluoromethylbenzenethiol
825-83-2

4-trifluoromethylbenzenethiol

(4-phenylbutyl)(4-(trifluoromethyl)phenyl)sulfane

(4-phenylbutyl)(4-(trifluoromethyl)phenyl)sulfane

Conditions
ConditionsYield
Stage #1: 4-phenyl-butan-1-ol With 1,2-Diiodoethane; N,N-dimethyl-formamide; triphenylphosphine at 20℃; for 0.0166667h; Sealed tube; Inert atmosphere;
Stage #2: 4-trifluoromethylbenzenethiol at 20℃; Sealed tube; Inert atmosphere;
100%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

sodium phenoxide
139-02-6

sodium phenoxide

(4-phenoxybutyl)benzene
358349-92-5

(4-phenoxybutyl)benzene

Conditions
ConditionsYield
Stage #1: 4-phenyl-butan-1-ol With 1,2-Diiodoethane; N,N-dimethyl-formamide; triphenylphosphine at 20℃; for 0.0166667h; Sealed tube; Inert atmosphere;
Stage #2: sodium phenoxide at 20℃; Sealed tube; Inert atmosphere;
100%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

sodium 4-methoxyphenolate
1122-95-8

sodium 4-methoxyphenolate

1-methoxy-4-(4-phenylbutoxy)benzene

1-methoxy-4-(4-phenylbutoxy)benzene

Conditions
ConditionsYield
Stage #1: 4-phenyl-butan-1-ol With 1,2-Diiodoethane; N,N-dimethyl-formamide; triphenylphosphine at 20℃; for 0.0166667h; Sealed tube; Inert atmosphere;
Stage #2: sodium 4-methoxyphenolate at 20℃; Sealed tube; Inert atmosphere;
100%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

potassium acetate
127-08-2

potassium acetate

4-phenylbutyl acetate
7492-40-2

4-phenylbutyl acetate

Conditions
ConditionsYield
Stage #1: 4-phenyl-butan-1-ol With 1,2-Diiodoethane; N,N-dimethyl-formamide; triphenylphosphine at 20℃; for 0.0166667h; Sealed tube; Inert atmosphere;
Stage #2: potassium acetate at 20℃; Sealed tube; Inert atmosphere;
100%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

4-phenylbutyl benzoate
857839-66-8

4-phenylbutyl benzoate

Conditions
ConditionsYield
With potassium hydroxide; benzoic acid99.7%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

1-Bromo-4-phenylbutane
13633-25-5

1-Bromo-4-phenylbutane

Conditions
ConditionsYield
With hydrogen bromide for 12h; Reagent/catalyst; Irradiation; Reflux;99.6%
With allyl bromide; 1,1'-carbonyldiimidazole In acetonitrile for 1h; Heating;98%
With carbon tetrabromide; triphenylphosphine In dichloromethane at 25℃;95%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

4-phenylbutyl methanesulfonate
65512-08-5

4-phenylbutyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;99%
With triethylamine In dichloromethane for 16h; Ambient temperature;96%
With triethylamine In dichloromethane at 5 - 10℃; for 1h;91%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

acetic acid
64-19-7

acetic acid

4-phenylbutyl acetate
7492-40-2

4-phenylbutyl acetate

Conditions
ConditionsYield
With iron(III) chloride at 20℃; for 1h; Esterification;99%
With tetrabutylammomium bromide; oxygen; sodium nitrite at 70℃; for 4h; Green chemistry;81%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

thioacetic acid
507-09-5

thioacetic acid

S-(4-phenylbutyl) ethanethioate
294201-60-8

S-(4-phenylbutyl) ethanethioate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 1.5h; thioacetylation;99%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

C10H6(2)H8O

C10H6(2)H8O

Conditions
ConditionsYield
With hydrogen; water-d2; palladium on activated charcoal at 110℃; under 760.051 Torr; for 24h;99%
4-Cyanochlorobenzene
623-03-0

4-Cyanochlorobenzene

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

4-(4-phenylbutoxy)benzonitrile
138631-41-1

4-(4-phenylbutoxy)benzonitrile

Conditions
ConditionsYield
Stage #1: 4-phenyl-butan-1-ol With sodium methylate In methanol at 130℃; for 2h;
Stage #2: 4-Cyanochlorobenzene In methanol at 100℃; for 15h; Reagent/catalyst; Temperature; Solvent;
98.1%
phthalimide
136918-14-4

phthalimide

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

2-(4-phenylbutyl)-1H-isoindole-1,3(2H)-dione
54981-87-2

2-(4-phenylbutyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With triphenylphosphine; 3,3-dimethyl-1,2,5-thiadiazolidine-1,1-dioxide In dichloromethane for 2.5h; Ambient temperature;98%
carbon dioxide
124-38-9

carbon dioxide

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

s-butyl bromide
78-76-2, 5787-31-5

s-butyl bromide

carbonic acid sec-butyl ester 4-phenyl-butyl ester

carbonic acid sec-butyl ester 4-phenyl-butyl ester

Conditions
ConditionsYield
Stage #1: carbon dioxide; 4-phenyl-butan-1-ol With tetra-(n-butyl)ammonium iodide; caesium carbonate In N,N-dimethyl-formamide at 23℃; for 1h;
Stage #2: s-butyl bromide In N,N-dimethyl-formamide at 23℃; for 23h;
98%
With tetra-(n-butyl)ammonium iodide; caesium carbonate In N,N-dimethyl-formamide at 23℃; for 4h;91%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

diphenyl (4-phenylbutyl) phosphate

diphenyl (4-phenylbutyl) phosphate

Conditions
ConditionsYield
With pyridine N-oxide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 20℃; for 2h; Reagent/catalyst; Inert atmosphere;98%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

2-(3,4,5-trimethoxyphenyl)acetonitrile
13338-63-1

2-(3,4,5-trimethoxyphenyl)acetonitrile

C21H25NO3

C21H25NO3

Conditions
ConditionsYield
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate In toluene at 135℃; for 4h; Inert atmosphere;98%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

1-Bromo-3-phenylpropane
637-59-2

1-Bromo-3-phenylpropane

C19H24O

C19H24O

Conditions
ConditionsYield
With cesium hydroxide; 4 A molecular sieve; tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 23℃; for 11h;97%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

benzyl bromide
100-39-0

benzyl bromide

(4-(benzyloxy)butyl)benzene
101747-16-4

(4-(benzyloxy)butyl)benzene

Conditions
ConditionsYield
With cesium hydroxide; 4 A molecular sieve In N,N-dimethyl-formamide at 23℃; for 3h;97%
Stage #1: 4-phenyl-butan-1-ol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: benzyl bromide In tetrahydrofuran; mineral oil at 20℃; for 12h; Inert atmosphere;
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

caesium carbonate
534-17-8

caesium carbonate

benzyl chloride
100-44-7

benzyl chloride

carbonic acid benzyl ester 4-phenyl-butyl ester

carbonic acid benzyl ester 4-phenyl-butyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 95℃; for 36h;97%
methyl 2-fluoro-4-hydroxybenzoate
197507-22-5

methyl 2-fluoro-4-hydroxybenzoate

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

methyl 4-(4-phenylbutoxy)-2-fluorobenzoate

methyl 4-(4-phenylbutoxy)-2-fluorobenzoate

Conditions
ConditionsYield
97%
[(p-cymene)Ru(OTf)2]
130830-27-2

[(p-cymene)Ru(OTf)2]

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

[(p-cymene)Ru(4-phenyl-1-butanol)][OTf]2

[(p-cymene)Ru(4-phenyl-1-butanol)][OTf]2

Conditions
ConditionsYield
In nitromethane (Ar); addn. of ligand to a mixt. of ruthenium complex and CH3NO2, heating to 60°C for 30 min; layering with CH2Cl2 and Et2O, standing overnight at -20°C, sepn., washing with CH2Cl2 and Et2O, drying in vac.; elem. anal.;97%

3360-41-6Relevant articles and documents

Young,Trahanovsky

, p. 5060,5062 (1969)

Selective hydroboration of equilibrating allylic azides

Liu, Ruzhang,Xu, Jun,Zhang, Yuanyuan

supporting information, p. 8913 - 8916 (2021/09/13)

The iridium(i)-catalyzed hydroboration of equilibrating allylic azides is reported to provide only the anti-Markovnikov product of alk-1-ene isomers in good yields and with good functional group tolerance.

Redox-active ligand based Mn(i)-catalyst for hydrosilylative ester reduction

Chakraborty, Soumi,Das, Arpan,Mandal, Swadhin K.

supporting information, p. 12671 - 12674 (2021/12/04)

Herein a Mn(i) catalyst bearing a redox-active phenalenyl (PLY) based ligand is reported for the efficient hydrosilylation of esters to alcohols using the inexpensive silane source polymethylhydrosiloxane (PMHS) under mild conditions. Mechanistic investigations suggest a strong ligand-metal cooperation where a ligand-based single electron transfer (SET) process initiates the reaction through Si-H bond activation.

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