155432-40-9

Upstream product

• 1027280-21-2 1-(2,2-diethoxy-ethyl)-3-(4-fluoro-phenyl)-urea 
• 155431-17-7 1-(4-fluorophenyl)-2(1H,3H)-imidazolone 
• 138373-69-0 (1S)-1-<(2S)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 1195-45-5 para-fluorophenyl isocyanate 
• 288-88-0 1,2,4-Triazole 

Relevant academic research and scientific papers

Optically active antifungal azoles. VIII synthesis and antifungal activity of 1-[(1R,2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-hydroxy-1- methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-substituted phenyl)2(1H,3H)- imidazolones and 2-imidazolidinones

New optically active antifungal azoles, 1-[(1R,2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4- substituted phenyl)-2(1H,3H)-imidazolones (1, 2) and 2-imidazolidinones (3, 4), were prepared in a stereocontrolled manner from (1S)-1-[(2R)-2-(2,4- difluoro- and 2-fluorophenyl)-2-oxi-ranyl]ethanols (15, 16). Compounds 1 - 4 showed potent antifungal activity against Candida albicans in vitro and in vivo, as well as a broad antifungal spectrum for various fungi in vitro. Furthermore, the imidazolidinones, 3b - e and 4d, e, were found to exert extremely strong growth-inhibitory activity against Aspergillus fumigatus.

Triazole and imidazole compounds and their use as antifungal therapeutic agents

The present invention provides an azole compound represented by the formula (I): STR1 wherein Ar is an optionally-substituted phenyl group; R1 and R2 are, the same or different, a hydrogen atom or a lower alkyl group, or R1/sup