1554387-89-1

Basic information

• Product Name: C₂₈H₂₆N₆O₂
• CAS NO: 1554387-89-1
• Molecular Weight: 478.553
• Mol File: 1554387-89-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₆N₆O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₆N₆O₂(1554387-89-1)
• EPA Substance Registry System: C₂₈H₂₆N₆O₂(1554387-89-1)

Safety Data

• Hazardous Substances Data: 1554387-89-1(Hazardous Substances Data)

Upstream product

• 51-71-8 Phenelzine 
• 159979-74-5 5-amino-4-cyano-1-(β-phenylethyl)pyrazole 
• 1554387-77-7 N-(3-aminobenzyl)-1-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1338789-07-3 1-(2-phenylethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 
• 1338789-08-4 4-chloro-1-(2-phenylethyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 1554387-74-4 N-(3-nitrobenzyl)-1-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 

Relevant articles and documents

Structure-based optimization of tyrosine kinase inhibitor CLM3. design, synthesis, functional evaluation, and molecular modeling studies.

Recent advances in the knowledge of thyroid carcinomas development identified receptor tyrosine kinases, like VEGFR2 and RET, as viable and promising targets. Accordingly, their inhibition is emerging as the major therapeutic strategy to treat these pathologies. In this study we describe the synthesis and the functional evaluation of three different series of 4-substituted pyrazolo[3,4-d]pyrimidine derivatives, 8a-g, 9a-g, and 10a-g, designed exploiting a structure-based optimization of the previously developed inhibitor CLM3. Compared to the lead, the novel compounds markedly improved both their inhibitory profile against the target proteins, VEGFR2 and RET, and their antiproliferative efficacy against the medullary thyroid cancer cell line TT. Significantly, compounds 8b, 9c, and 10c proved to block the kinase activity of the mutant RETV804L, which still lacks effective inhibitors.