1554414-95-7Relevant academic research and scientific papers
Synthesis of triazole-functionalized 2-DOS analogues and their evaluation as A-site binders
Anastasopoulou, Panoula,Kythreoti, Georgia,Cosmidis, Tilemachos,Pyrkotis, Constantina,Nahmias, Victoria R.,Vourloumis, Dionisios
, p. 1122 - 1126 (2014/03/21)
Aminoglycoside-antibiotics represent important tools for studying the biological functions of RNA. An orthogonal protection strategy applied on 2-deoxystreptamine (2-DOS) revealed a series of key intermediates that enable its regioselective functionalization. Our approach allowed the construction of selected representatives of triazole-containing analogues with diverse molecular frameworks for biological evaluation regarding their binding and antibacterial potencies.
