1554422-01-3

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 1554422-00-2 C₁₀H₁₃N₃O₂ 
• 107-19-7 propargyl alcohol 

Downstream Products

• 1554414-95-7 4-(bromomethyl)-1-(2-((4-methoxybenzyl)oxy)ethyl)-1H-1,2,3-triazole 
• 1554422-07-9 1-((1R,2S,3R,4R,5S)-5-azido-2-hydroxy-4-((1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-(2-morpholino-2-oxoethoxy)cyclohexyl)-3-(2-hydroxyethyl)urea 
• 1554422-09-1 C₂₀H₃₃N₉O₈ 

Relevant academic research and scientific papers

Synthesis of triazole-functionalized 2-DOS analogues and their evaluation as A-site binders

Aminoglycoside-antibiotics represent important tools for studying the biological functions of RNA. An orthogonal protection strategy applied on 2-deoxystreptamine (2-DOS) revealed a series of key intermediates that enable its regioselective functionalization. Our approach allowed the construction of selected representatives of triazole-containing analogues with diverse molecular frameworks for biological evaluation regarding their binding and antibacterial potencies.