155444-28-3

Usage

Uses

Used in Pharmaceutical Synthesis:
N-(3-Bromo-2-pyridinyl)-acetamide is utilized as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows it to be a key component in the development of new medications.
Used in Agrochemical Production:
In the agrochemical sector, N-(3-Bromo-2-pyridinyl)-acetamide serves as an intermediate in the production of crop protection agents and other agricultural chemicals, contributing to the development of effective pest control solutions.
Used in Research and Development of Novel Compounds:
N-(3-Bromo-2-pyridinyl)-acetamide is employed as a building block in the research and development of new biologically active compounds, potentially leading to breakthroughs in medicinal chemistry.
Used in Antifungal and Antimicrobial Drug Development:
Due to its antifungal and antimicrobial properties, N-(3-Bromo-2-pyridinyl)-acetamide is used in the development of new drugs and treatments targeting a range of infections, thereby expanding the arsenal of available therapeutic options.

InChI:InChI=1/C7H7BrN2O/c1-5(11)10-7-6(8)3-2-4-9-7/h2-4H,1H3,(H,9,10,11)

Upstream product

• 626-55-1 3-Bromopyridine 
• 75-05-8 acetonitrile 
• 13534-99-1 2-Amino-3-bromopyridine 
• 108-24-7 acetic anhydride 
• 5231-96-9 N-(2-pyridyl)acetamide 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1003961-43-0 2-{3-[acetyl-(3-bromo-pyridin-2-yl)-amino]-propenyl}-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Carboxamidation of pyridines by the system of elemental fluorine- carbonitrile-water: A useful alternative to the chichibabin amination

The title reaction with pyridine, 4-methylpyridine, 3-methylpyridine, 3- bromopyridine, nicotinonitrile, and quinoline yields 2-carboxamido derivatives regioselectively. Isoquinoline is amidated at position 1.

Monoprotected l-Amino Acid (l-MPAA), Accelerated Bromination, Chlorination, and Iodination of C(sp2)?H Bonds by Iridium(III) Catalysis

Halogenated arenes are important structural motifs commonly found in biologically active molecules and used for a variety of transformations in organic synthesis. Herein, we report the mono-protected l-amino acid (l-MPAA) accelerated iridium(III)-catalyzed halogenation of (hetero)anilides at room temperature. This reaction constitutes the first example of an iridium(III)/l-MPAA-catalyzed general halogenation of (hetero)arenes through C(sp2)?H activation. Furthermore, we demonstrate the potential utility of our method through its use in the synthesis of a quinolone derivative.

Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors

To identify a new non-peptidyl BACE1 inhibitor, we focused on the aminopyridine structure, which binds to the active sites of BACE1. Synthesis of aminopyridine derivatives and evaluation of inhibitory activity against rBACE1 are described. The 2-aminopyri

C-RING MODIFIED TRICYCLIC BENZONAPHTHIRIDINONE PROTEIN KINASE INHIBITORS AND USE THEREOF

Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to prote

Fused heterotricyclic compounds as inhibitors of 17beta-hydroxysteroid dehydrogenase 3

Fused heterotricyclic compounds, methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions containing such compounds.

New access to oxazolopyridines via hydroxyamidine derivatives; application to quinolines

Several 2-aryl and 2-heteroaryloxazolo[4,5-b]pyridines were synthesised in high yields from zwitterion or hydroxyamidine derivatives by heating in dimethylacetamide. These intermediates were generated via hetarynic reaction with the complex base NaNH2-t-BuONa (5:2). The same reactions were possible with quinoline derivatives.

Synthesis and NMR Spectra of the Six Isomeric Thieno

Through the use of Pd(0)-catalyzed coupling between 2- and 4-formyl-3-thiopheneboronic acid and 4-iodo-3-aminopyridine (1) and 3-bromo-2-aminopyridine, convenient one-pot procedures for the preparation of thieno-1,7-naphthyridine (2), thieno-1,7-naphthyridine (3), thieno-1,8-naphthyridine (6) and thieno-1,8-naphthyridine (7) have been developed.Thieno-1,7-naphthyridine (4) and thieno-fused 1,7- and 1,6-naphthyridines are discussed.