1554455-85-4Relevant academic research and scientific papers
Metal-free oxidative amidation of 2-oxoaldehydes: A facile access to α-ketoamides
Mupparapu, Nagaraju,Khan, Shahnawaz,Battula, Satyanarayana,Kushwaha, Manoj,Gupta, Ajai Prakash,Ahmed, Qazi Naveed,Vishwakarma, Ram A.
, p. 1152 - 1155 (2014/03/21)
A novel and efficient method for the synthesis of α-ketoamides, employing a dimethyl sulfoxide (DMSO)-promoted oxidative amidation reaction between 2-oxoaldehydes and amines under metal-free conditions is presented. Furthermore, mechanistic studies supported an iminium ion-based intermediate as a central feature of reaction wherein C1-oxygen atom of α-ketoamides is finally derived from DMSO.
A general metal free approach to α-ketoamides via oxidative amidation-diketonization of terminal alkynes
Deshidi, Ramesh,Kumar, Manjeet,Devari, Shekaraiah,Shah, Bhahwal Ali
supporting information, p. 9533 - 9535 (2014/08/18)
A novel catalytic system TMSOTf/I2/DMSO for the oxidative coupling of terminal alkynes with virtually any primary/secondary amine leading to α-ketoamides has been developed. The reaction possibly proceeds via iminium ion formation, wherein DMSO acts as a solvent as well as an oxidizing agent. This journal is the Partner Organisations 2014.
