155474-10-5Relevant academic research and scientific papers
Preparation of phenanthrenes by photocyclization of stilbenes containing a tosyl group on the central double bond. A versatile approach to the synthesis of phenanthrenes and phenanthrenoids
Neo, Ana G.,Lopez, Carmen,Romero, Victor,Antelo, Berta,Delamano, Jose,Perez, Antonio,Fernandez, Dolores,Almeida, Jesus F.,Castedo, Luis,Tojo, Gabriel
supporting information; experimental part, p. 6764 - 6770 (2010/12/19)
We have developed a useful modification of the classical preparation of phenanthrenes by UV irradiation of stilbenes in the presence of an oxidant. This modification involves the irradiation, in the presence of base, of stilbenes possessing a sulfonyl group linked to the central double bond. We have proved that this protocol can be successfully applied for the synthesis of diverse phenanthrenes and phenanthrenoids.
Photocyclization of tosylstilbenes as a key reaction in the preparation of an analogue of the antitumor agent CC-1065
Neo, Ana G.,Perez, Antonio,Lopez, Carmen,Castedo, Luis,Tojo, Gabriel
scheme or table, p. 3203 - 3206 (2009/08/15)
A photocyclization of tosylstilbenes in the presence of base is used as a key reaction in the synthesis of the CC-1065 analogue 5.
Base-Induced Photocyclization of 1,2-Diaryl-1-tosylethenes. A Mechanistically Novel Approach to Phenanthrenes and Phenanthrenoids
Almeida, Jesus F.,Castedo, Luis,Fernandez, Dolores,Neo, Ana G.,Romero, Victor,Tojo, Gabriel
, p. 4939 - 4941 (2007/10/03)
(Equation presented) The irradiation with UV light of a number of 1,2-diaryl-1-tosylstilbenes, in the presence of base, leads to the corresponding phenanthrenes and heterocyclic analogues. These results are consistent with a mechanism involving the base-induced elimination of p-toluenesulfinic acid from an intermediate 9-tosyl-4a,4b-dihydrophenanthrene, formed by photochemical cyclization of the starting 1,2-diaryl-1-tosylstilbenes.
Areno [E]indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity
-
, (2008/06/13)
The areno[e]indols have the formula (I). The methods comprises: (a) reacting (VI) with an aldehyde Ar"--CHO to obtain (VII); (b) oxidizing (VII) to yield the cetone (VIII); (c) reating (VIII) with a strong base and thereafter with an acycle chloride ClCOR
