52091-37-9

Basic information

• Product Name: 1H-Imidazole, 2-(4-methoxyphenyl)-
• CAS NO: 52091-37-9
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Mol File: 52091-37-9.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 2-(4-methoxyphenyl)-(52091-37-9)
• EPA Substance Registry System: 1H-Imidazole, 2-(4-methoxyphenyl)-(52091-37-9)

Safety Data

• Hazardous Substances Data: 52091-37-9(Hazardous Substances Data)

Usage

Structure

An imidazole derivative with a 4-methoxyphenyl group attached to the second carbon atom of the imidazole ring

Biological activities

Antimicrobial, antifungal, and antiparasitic properties

Uses

Building block in the synthesis of pharmaceutical drugs and other organic compounds

Potential applications

Treatment of various diseases, including cancer and neurological disorders

Importance

Versatile chemical with significant applications in medicinal chemistry and pharmaceutical research.

Upstream product

• 100-66-3 methoxybenzene 
• 50846-98-5 2-Diazo-2H-imidazole 
• 100-07-2 4-methoxy-benzoyl chloride 
• 107-15-3 ethylenediamine 
• 288-32-4 1H-imidazole 
• 104-94-9 4-methoxy-aniline 
• 123-11-5 4-methoxy-benzaldehyde 
• 696-62-8 para-iodoanisole 
• 6302-84-7 2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazole 

Downstream Products

• 33469-37-3 2-(4-methoxyphenyl)-4-(trifluoromethyl)-imidazole 
• 160730-42-7 (6aR,9R,10aR)-9-[2-(4-Methoxy-phenyl)-imidazol-1-ylmethyl]-7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline 
• 115053-29-7 1-amino-2-(4-methoxyphenyl)imidazole 
• 1160826-49-2 C₁₇H₁₃N₃O₄ 
• 1160826-54-9 C₁₇H₁₃BrN₂O₂ 
• 1400866-41-2 C₁₉H₁₈ClN₃O₂ 
• 1301603-06-4 C₂₉H₄₉N₂O⁽¹⁺⁾*I^(1-) 
• 137208-86-7 4-(1-methyl-1H-imidazol-2-yl)phenol 
• 15548-89-7 2-(4-hydroxyphenyl)-1H-imidazole 
• 700875-16-7 2-(4-methoxyphenyl)-1-(phenylsulfonyl)-1H-imidazole 
• 700875-17-8 4-(p-methoxybenzoyl)-2-(p-methoxyphenyl)-3H-imidazole 

Relevant articles and documents

New Insights into the Role of Imidazolium-Based Promoters for the Electroreduction of CO2 on a Silver Electrode

The electrochemical reduction of CO2 to CO is a reaction of central importance for sustainable energy conversion and storage. Herein, structure-activity relationships of a series of imidazolium-based cocatalysts for this reaction are described,

Formation and propagation of well-defined Pd nanoparticles (PdNPs) during C-H bond functionalization of heteroarenes: Are nanoparticles a moribund form of Pd or an active catalytic species?

Abstract Examination of a series of C-H bond functionalization reactions of heteroarenes (e.g., indole, benzoxazole, benzthiazole, benzimidazole and purine derivatives) mediated by Pd(OAc), a commonly used C-H bond functionalization catalyst, reveals that well-defined Pd nanoparticles (PdNPs) are rapidly formed under working catalyst conditions. The PdNPs can be characterized ex situ after entrapment in a polymer matrix (polyvinylpyrrolidinone, PVP). Independently synthesized Pd(PVP)NPs are catalytically competent species, exhibiting catalyst activity commensurate with Pd(OAc) in several C-H bond functionalization reactions. Across a range of reactions, Pd concentration is a common variable, which can be linked to the propagation of PdNPs under working catalytic conditions using polar solvents like DMF, DMSO and acetic acid.

Multi-wall carbon nanotube supported manganese(III) porphyrin: An efficient and reusable catalyst for oxidation of 2-imidazolines with sodium periodate

The oxidation of 2-substituted imidazolines with sodium periodate catalyzed by tetrakis(p-aminophenyl)-porphyrinatomanganese(III) chloride, [Mn(TNH 2PP)Cl], supported on functionalized multi-wall carbon nanotubes is reported. A wide variety of 2-imidazolines were efficiently converted to their corresponding imidazoles by this catalytic system. When the same reaction was subjected to ultrasonic irradiation, the reaction times were reduced significantly and the product yields were increased. This catalyst could be reused several times without significant loss of activity. The effects of reaction parameters such catalyst amount, choice of solvent, and the effects of ultrasonic irradiation on the catalytic activity have been investigated.