52091-37-9Relevant academic research and scientific papers
New Insights into the Role of Imidazolium-Based Promoters for the Electroreduction of CO2 on a Silver Electrode
Lau, Genevieve P. S.,Schreier, Marcel,Vasilyev, Dmitry,Scopelliti, Rosario,Gr?tzel, Michael,Dyson, Paul J.
supporting information, p. 7820 - 7823 (2016/07/07)
The electrochemical reduction of CO2 to CO is a reaction of central importance for sustainable energy conversion and storage. Herein, structure-activity relationships of a series of imidazolium-based cocatalysts for this reaction are described,
Fe3O4/SiO2/(CH2)3N+Me3Br3- core-shell nanoparticles: A novel catalyst for the solvent-free synthesis of five- and six-membered heterocycles
Farrokhi, Azita,Ghodrati, Keivan,Yavari, Issa
, p. 41 - 46 (2015/02/19)
Functionalized magnetic core-shell nanoparticles [Fe3O4/SiO2/(CH2)3N+Me3Br3-] are prepared by co-precipitation method, characterized by transmission electron microscopy, FT-IR, X-ray diffraction, and vibrating sample magnetometer. The catalytic activity of these nanoparticles was tested in the syntheses of imidazole, benzothiazole, and perimidine derivatives, under solvent-free conditions. The catalyst was readily recycled by the use of an external magnetic field and could be reused five times without significant loss of activity or mass.
Formation and propagation of well-defined Pd nanoparticles (PdNPs) during C-H bond functionalization of heteroarenes: Are nanoparticles a moribund form of Pd or an active catalytic species?
Baumann, Christoph G.,De Ornellas, Sara,Reeds, Jonathan P.,Storr, Thomas E.,Williams, Thomas J.,Fairlamb, Ian J.S.
, p. 6174 - 6187 (2015/04/14)
Abstract Examination of a series of C-H bond functionalization reactions of heteroarenes (e.g., indole, benzoxazole, benzthiazole, benzimidazole and purine derivatives) mediated by Pd(OAc), a commonly used C-H bond functionalization catalyst, reveals that well-defined Pd nanoparticles (PdNPs) are rapidly formed under working catalyst conditions. The PdNPs can be characterized ex situ after entrapment in a polymer matrix (polyvinylpyrrolidinone, PVP). Independently synthesized Pd(PVP)NPs are catalytically competent species, exhibiting catalyst activity commensurate with Pd(OAc) in several C-H bond functionalization reactions. Across a range of reactions, Pd concentration is a common variable, which can be linked to the propagation of PdNPs under working catalytic conditions using polar solvents like DMF, DMSO and acetic acid.
COMPOUNDS FOR TREATMENT OF CANCER
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Paragraph 00222; 00246, (2014/09/29)
The present invention relates to pharmaceutical compositions for treating cancer comprising BRAF inhibitors, (e.g. vemurafenib) and/or MEK inhibitor, (e.g. trametinib, RO5068760), in combination with anti-tubulin compounds of the invention or other known tubulin inhibitors, and using such compositions for treating cancer such as melanoma, drug-resistant cancer, and cancer metastasis.
Multi-wall carbon nanotube supported manganese(III) porphyrin: An efficient and reusable catalyst for oxidation of 2-imidazolines with sodium periodate
Kargar, Hadi,Moghadam, Majid,Mirkhani, Valiollah,Tangestaninejad, Shahram,Mohammadpoor-Baltork, Iraj,Rezaei, Simindokht
, p. 1 - 5 (2013/08/24)
The oxidation of 2-substituted imidazolines with sodium periodate catalyzed by tetrakis(p-aminophenyl)-porphyrinatomanganese(III) chloride, [Mn(TNH 2PP)Cl], supported on functionalized multi-wall carbon nanotubes is reported. A wide variety of 2-imidazolines were efficiently converted to their corresponding imidazoles by this catalytic system. When the same reaction was subjected to ultrasonic irradiation, the reaction times were reduced significantly and the product yields were increased. This catalyst could be reused several times without significant loss of activity. The effects of reaction parameters such catalyst amount, choice of solvent, and the effects of ultrasonic irradiation on the catalytic activity have been investigated.
Synthesis, antimycobacterial activities and Docking studies of some novel diaryl imidazoles targeted at mycobacterium tuberculosis P-45014DM
Ganguly, Swastika,Nagaraj,Sriram
, p. 323 - 330 (2013/09/24)
A novel series of nine 2-(substituted phenyl)-1H-imidazol-1-yl-N- (substituted phenyl) alkanamides 3a-i were synthesized by reacting the corresponding w-chloroalkanamides 1 with 2-(substituted phenyl)-1H-imidazoles 2 in dimethylformamide. The compounds have been characterized on the basis of elemental analysis and spectral data. All the compounds were evaluated for their antimycobacterial activity. Among the synthesized compounds, N-(2,4-dinitrophenyl)-2-(2-(2-nitrophenyl)-1 H-imidazol-2-yl) propanamide 3e showed significant antimycobacterial activity when compared with the standard drug ethambutol. Docking studies with 14-a-demethylase (PDB ID IEA1) were also performed in order to investigate the binding pattern of these compounds.
Rapid and efficient biomimetic oxidation of 2-imidazolines to their corresponding imidazoles with NaIO4 catalyzed by Mn(salophen)Cl
Kargar, Hadi
experimental part, p. 863 - 866 (2011/06/25)
Rapid and efficient oxidation of 2-substituted imidazolines with sodium periodate is reported. The Mn(III)-salophen/NaIO4 catalytic system efficiently converted 2-imidazolines to their corresponding imidazoles at room temperature in 2: 1, CH3CN/H2O mixture.
Oxidation of 2-imidazolines to 2-imidazoles with sodium periodate catalyzed by polystyrene-bound manganese(III) porphyrin
Kargar, Hadi,Moghadam, Majid,Mirkhani, Valiollah,Tangestaninejad, Shahram,Mohammadpoor-Baltork, Iraj,Naghipour, Mahmood
experimental part, p. 1463 - 1468 (2011/06/27)
In the present work, the dehydrogenation of 2-substituted imidazolines with sodium periodate in the presence of tetraphenylporphyrinatomanganese(III) chloride supported on polystyrene-bound imidazole, [Mn(TPP)Cl@PSI] is reported. A wide variety of 2-imidazolines were efficiently converted to their corresponding imidazoles by the [Mn(TPP)Cl@PSI]/NaIO4 catalytic system in a 1:2 CH3CN/H2O mixture under agitation with magnetic stirring. Ultrasonic irradiation enhanced the catalytic activity of this catalyst in the oxidation of 2-imidazolines and this led to shorter reaction times and higher product yields. This catalyst could be reused several times without significant loss of its catalytic activity.
Dehydrogenation of 2-imidazolines with sodium periodate catalyzed by manganese(III) tetraphenylporphyrin
Kargar, Hadi,Moghadam, Majid,Mirkhani, Valiollah,Tangestaninejad, Shahram,Mohammadpoor-Baltork, Iraj,Nameni, Iman
experimental part, p. 2146 - 2148 (2011/04/24)
In the present work, dehydrogenation of 2-substituted imidazolines with sodium periodate in the presence of tetraphenylporphyrinatomanganese(III) chloride, [Mn(TPP)Cl], is reported. A wide variety of 2-imidazolines efficiently converted to their corresponding imidazoles by [Mn(TPP)Cl]/NaIO4 catalytic system at room temperature in 1:2, CH3CN/H2O mixture. The effect of reaction parameters such as kind of solvent and catalyst amount was also investigated.
T-shaped ionic liquid crystals based on the imidazolium motif: Exploring substitution of the C-2 imidazolium carbon atom
Goossens, Karel,Wellens, Sil,Vana Hecke, Kristof,Van Meervelt, Luc,Cardinaels, Thomas,Binnemans, Koen
supporting information; experimental part, p. 4291 - 4306 (2011/05/15)
In this contribution the first examples of so-called rigid-core, T-shaped imidazolium ionic liquid crystals, in which the C-2 atom of the imidazolium ring is substituted with an aryl moiety decorated with one or two alkoxy chains, are described. The length of the alkoxy chain(s) was varied from six to eighteen carbon atoms (n=6, 10, 14-18). Whereas the compounds with one long alkoxy chain display only smectic A phases, the salts containing two alkoxy chains exhibit smectic A, multicontinuous cubic, as well as hexagonal columnar phases, as evidenced by polarising optical microscopy, differential scanning calorimetry, and powder X-ray diffraction. Structural models are proposed for the self-assembly of the molecules within the mesophases. The imidazolium head groups and the iodide counterions were found to adopt a peculiar orientation in the central part of the columns of the hexagonal columnar phases. The enantiotropic cubic phase shown by the 1,3-dimethyl-2-[3,4-bis(pentadecyloxy) phenyl]imidazolium iodide salt has a multicontinuous Pmβar 3μ structure. To the best of our knowledge, this is the first example of a thermotropic cubic mesophase of this symmetry. Copyright
