155480-08-3 Usage
Uses
Used in Organic Synthesis:
(1,1-Dioxothiomorpholino)acetic acid monohydrate is used as a reagent in organic synthesis for its ability to contribute to the formation of complex organic molecules, facilitating the creation of a wide range of chemical products.
Used in Pharmaceutical and Agrochemical Preparation:
In the pharmaceutical industry, (1,1-Dioxothiomorpholino)acetic acid monohydrate serves as a building block for the preparation of various compounds, playing a crucial role in the development of new medications. Similarly, in agrochemicals, it is utilized in the synthesis of compounds that can be used in crop protection and other agricultural applications.
Used in Chiral Ligand and Catalyst Production:
(1,1-Dioxothiomorpholino)acetic acid monohydrate is used as a precursor in the production of chiral ligands and catalysts, which are essential for asymmetric synthesis. This application is vital for the creation of enantiomerically pure compounds, often required in pharmaceuticals to ensure desired biological activity and minimize side effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (1,1-Dioxothiomorpholino)acetic acid monohydrate has potential applications in the development of new drugs. Its unique structural features make it a valuable component in the design and synthesis of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 155480-08-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,4,8 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 155480-08:
(8*1)+(7*5)+(6*5)+(5*4)+(4*8)+(3*0)+(2*0)+(1*8)=133
133 % 10 = 3
So 155480-08-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO4S/c8-6(9)5-7-1-3-12(10,11)4-2-7/h1-5H2,(H,8,9)
155480-08-3Relevant articles and documents
Design, synthesis and biological evaluation of protease inhibitors containing morpholine cores with remarkable potency against both HIV-1 subtypes B and C
Cen, Shan,Ding, Jiwei,Dong, Biao,Ma, Ling,Shan, Qi,Wang, Juxian,Wang, Minghua,Wang, Yucheng,Zhang, Guoning,Zhou, Huiyu,Zhou, Jinming,Zhu, Mei
, (2022/03/15)
By following up on the design vector of optimizing amine-based HIV-1 protease inhibitors, we have designed and biologically evaluated a novel class of inhibitors with the free nitrogen or sulphone in morpholine cores as P2 ligands in combination with diverse substituted phenylsulfonamide P2′ ligands. As it turns out, a majority of these inhibitors exhibit prominent enzymatic inhibitory activity in low nanomolar ranges with relatively low cytotoxicity. Particularly, inhibitor 1e containing a morpholine carboxamide P2 ligand and a 4-hydroxyphenylsulfonamide P2′ ligand illustrates a robust enzyme inhibitory IC50 value of 90 pM. Furthermore, 1e demonstrates impressive in vivo antiviral activity with EC50 value of 89 nM and a degree of inhibitory potency against the DRV-resistant variant. More importantly, 1e exhibits remarkable activity with EC50 values of 13.59 nM and 8.23 nM against subtype C HIV-1 strains ZM246 and Indie, respectively. Furthermore, the in silico studies provide molecular insights into binding features of inhibitors with HIV-1 protease, and furnish a valuable forecast on further process.
