155496-72-3

Upstream product

• 161431-82-9 2-tert-Butylsulfanyl-N,N-diisopropyl-benzamide 
• 20383-28-2 N,N-diisopropyl benzamide 

Downstream Products

• 20383-28-2 N,N-diisopropyl benzamide 
• 5448-36-2 3-methyl-N,N-diisopropylbenzamide 
• 155496-73-4 2-(tert-butylsulfonyl)-N,N-diisopropyl-5-methylbenzamide 
• 132464-42-7 N,N-diisopropyl-4′-methyl-[1,1′-biphenyl]-2-carboxamide 
• 103681-91-0 N,N-diisopropyl-[1,1'-biphenyl]-2-carboxamide 
• 120270-41-9 N,N-diisopropyl-2'-methyl-[1,1'-biphenyl]-2-carboxamide 

Relevant academic research and scientific papers

Nickel-catalysed Substitutions of Aryl tert-Butyl Sulfones with Organometallic Reagents: Synthesis of ortho-Substituted Unsymmetrical Biaryls

In the presence of a catalytic amount of a nickel salt, aryl tert-butyl sulfones react with aryl Grignard reagents to give biaryls.This reaction is used in conjunction with the powerful ortho-lithiation-directing ability of aryl tert-butyl sulfonyl groups to make unsymmetrical ortho-substituted biaryls.In certain cases, the substitution of an aryl alkylsulfonyl group by an organometallic reagent is possible without a transition metal catalyst.

ortho-Substituted Unsymmetrical Biaryls from Aryl tert-Butyl Sulfones

Nickel-catalysed coupling of arylmagnesium halides with aryl tert-butyl sulfones, and in particular with those bearing ortho-substituents introduced by ortholithiation, gives ortho-substituted unsymmetrical biaryls.