161431-82-9Relevant academic research and scientific papers
ortho-Substituted Unsymmetrical Biaryls from Aryl tert-Butyl Sulfones
Clayden, Jonathan,Julia, Marc
, p. 1682 - 1683 (1993)
Nickel-catalysed coupling of arylmagnesium halides with aryl tert-butyl sulfones, and in particular with those bearing ortho-substituents introduced by ortholithiation, gives ortho-substituted unsymmetrical biaryls.
Nickel-catalysed Substitutions of Aryl tert-Butyl Sulfones with Organometallic Reagents: Synthesis of ortho-Substituted Unsymmetrical Biaryls
Clayden, Jonathan,Cooney, J. Jonathan A.,Julia, Marc
, p. 7 - 14 (2007/10/02)
In the presence of a catalytic amount of a nickel salt, aryl tert-butyl sulfones react with aryl Grignard reagents to give biaryls.This reaction is used in conjunction with the powerful ortho-lithiation-directing ability of aryl tert-butyl sulfonyl groups to make unsymmetrical ortho-substituted biaryls.In certain cases, the substitution of an aryl alkylsulfonyl group by an organometallic reagent is possible without a transition metal catalyst.
