1555-56-2

Usage

Uses

Used in Food Industry:
ALPHA-GLYCEROPHOSPHORIC ACID DISODIUM SALT is used as a food additive for its ability to enhance the flavor and stability of various food products.
Used in Pharmaceutical Industry:
ALPHA-GLYCEROPHOSPHORIC ACID DISODIUM SALT is used as a buffering agent to maintain the pH balance in pharmaceutical formulations, ensuring the stability and efficacy of the drugs.
Used in Cosmetic Industry:
ALPHA-GLYCEROPHOSPHORIC ACID DISODIUM SALT is used as a component in cosmetic products to support skin health and maintain the integrity of the formulations.
Used in Therapeutic Applications:
ALPHA-GLYCEROPHOSPHORIC ACID DISODIUM SALT is used as a potential treatment for muscle fatigue, cognitive decline, and neurological disorders due to its role in energy production and cell membrane maintenance.

InChI:InChI=1/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2

Upstream product

• 56-81-5 glycerol 
• 106-89-8 epichlorohydrin 

Downstream Products

• 1190-00-7 2-aminoethyl 2,3-dihydroxypropyl hydrogen phosphate 

Relevant academic research and scientific papers

Method for preparing beta-sodium glycerophosphate

The invention provides a method for preparing beta-sodium glycerophosphate. The method comprises the following steps of: (a) esterification and cyclization, namely heating a glycerinum and inorganic phosphate mixture to 120-150 DEG C for reaction to 120-168 hours; (b) hydrolysis, namely adding a proper amount of water and 30% of a sodium hydroxide solution, carrying out temperature reaction on the reaction liquid for 8-20 hours, sampling and detecting the content of inorganic phosphorus of the solution, adding a proper amount of magnesium oxide according to the detected content of the inorganic phosphorus, stirring the solution for 3-5 hours and filtering the solution; (c) devitrification, namely cooling filtrate to 20-30 DEG C, dripping ethanol, cooling the filtrate to 0-5 DEG C for devitrification for 12-28 hours, filtering the product and washing the solid with ethanol to obtain a crude product; and (d) refining, dissolving the obtained crude product with water, adding ethanol or methanol at 20-30 DEG C, cooling the solution to 0-5 DEG C, carrying out devitrification for 12-28 hours and filtering and washing to obtain a primary refined wet product.

ENZYMATIC SYNTHESIS OF PHOSPHORIC MONOESTERS WITH ALKALINE PHOSPHATASE IN REVERSE HYDROLYSIS CONDITIONS

Title compounds were synthesized on a preparative scale using alkaline phosphatase, orthophosphoric monoester phosphohydrolase E.C. 3.1.3.1., in reverse hydrolysis conditions.Optimization for one of the 25 phosphoryl acceptors investigated (glycerol) shows that up to 55percent synthesis yield can be obtained using a large excess of substrate, conditions in which the enzymatic activity remains high.From the results obtained with different phosphoryl group donors, phosphate, pyrophosphate and polyphosphates and with enzymes of different sources, it comes up that the best results are obtained with pyrophosphate and with the weakly purified calf intestine alkaline phosphatase.The extent of enzymatic hydrolysis of the donor can be reduced owing to the existence of two different pH optima for the two reactions, phosphorylation and hydrolysis.The synthesis can be also performed using inert co-solvents which allow to reduce the amount of acceptor used, as long as Zn++ is added to the reaction medium.The results are discussed in terms of the catalytic mechanism of alkaline phosphatase.