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HYDROXYFASUDIL MONOHYDROCHLORIDE is a cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil) that exhibits anti-anginal properties. It functions as an ATP-competitive and reversible inhibitor of Rho-kinase (ROCK) with approximately 100-fold greater selectivity over MLCK, MRCKβ, and PKC. HYDROXYFASUDIL MONOHYDROCHLORIDE is known to inhibit Rho kinase-mediated contraction both in vitro and in vivo and is characterized by its off-white solid appearance.

155558-32-0

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155558-32-0 Usage

Uses

Used in Pharmaceutical Industry:
HYDROXYFASUDIL MONOHYDROCHLORIDE is used as a therapeutic agent for treating conditions related to Rho kinase-mediated contraction. Its application reason is due to its ability to inhibit ROCK, which can help alleviate anginal symptoms and potentially provide relief for patients suffering from various cardiovascular issues.
Used in Research Applications:
In the field of research, HYDROXYFASUDIL MONOHYDROCHLORIDE is used as a biochemical tool for studying the role of Rho kinase in cellular processes. Its application reason is its ATP-competitive and reversible inhibition of ROCK, which allows researchers to investigate the effects of ROCK inhibition on cellular functions and signaling pathways.
Used in Drug Development:
HYDROXYFASUDIL MONOHYDROCHLORIDE is utilized as a lead compound in the development of new drugs targeting Rho kinase. Its application reason is its potent and selective inhibition of ROCK, which makes it a promising candidate for the treatment of diseases where ROCK plays a significant role, such as cardiovascular diseases, neurological disorders, and cancer.

Biochem/physiol Actions

Cell permeable: yes

Check Digit Verification of cas no

The CAS Registry Mumber 155558-32-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,5,5 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 155558-32:
(8*1)+(7*5)+(6*5)+(5*5)+(4*5)+(3*8)+(2*3)+(1*2)=150
150 % 10 = 0
So 155558-32-0 is a valid CAS Registry Number.

155558-32-0 Well-known Company Product Price

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  • Sigma

  • (H4413)  Hydroxyfasudil hydrochloride hydrate  ≥98% (HPLC), solid

  • 155558-32-0

  • H4413-5MG

  • 2,352.87CNY

  • Detail
  • Sigma

  • (H4413)  Hydroxyfasudil hydrochloride hydrate  ≥98% (HPLC), solid

  • 155558-32-0

  • H4413-25MG

  • 8,985.60CNY

  • Detail

155558-32-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one,hydrochloride

1.2 Other means of identification

Product number -
Other names Hydroxyfasudil monohydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:155558-32-0 SDS

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