1555641-98-9Relevant academic research and scientific papers
Synthesis of 3-substituted N-allylisoindolinone derivatives by the acetate method
Ali, Ibrahim A. I.
, p. 803 - 810 (2014/05/20)
A series of N-allylisoindolinone derivatives were prepared by a novel sequential reaction of 2-allyl-3-oxoisoindolin-1-yl acetate with C-nucleophiles in the presence of trimethylsilyl trifluoromethanesulfonate. The nucleophiles included arenes, alkenes, and active methylene to give 3-substituted N-allylisoindolinone products. This method was applied to synthesize cyclohexane-fused indolizidine alkaloid mimics using Grubbs' catalyst. Graphical abstract: [Figure not available: see fulltext.].
