155588-21-9

Basic information

• Product Name: 7-triethylsilyl-13-dehydro-10-deacetylbaccatin III
• Synonyms: 7-triethylsilyl-13-dehydro-10-deacetylbaccatin III
• CAS NO: 155588-21-9
• Molecular Weight: 656.846
• Mol File: 155588-21-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 7-triethylsilyl-13-dehydro-10-deacetylbaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 7-triethylsilyl-13-dehydro-10-deacetylbaccatin III(155588-21-9)
• EPA Substance Registry System: 7-triethylsilyl-13-dehydro-10-deacetylbaccatin III(155588-21-9)

Safety Data

• Hazardous Substances Data: 155588-21-9(Hazardous Substances Data)

Upstream product

• 115437-21-3 7-(triethylsilyl)baccatin III 
• 150665-56-8 7-O-triethylsilyl-13-keto baccatin III 
• 155588-12-8 C₃₁H₄₄O₁₁Si 
• 155588-11-7 C₂₉H₄₂O₁₀Si 
• 155588-19-5 C₂₈H₄₄O₉Si 
• 994-30-9 triethylsilyl chloride 
• 32981-86-5 10-deacetylbaccatin III 
• 92950-42-0 13-dehydro-10-deacetylbaccatin III 
• 591-51-5 phenyllithium 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 

Downstream Products

• 33069-62-4 taxol 
• 115437-21-3 7-(triethylsilyl)baccatin III 
• 155588-13-9 (2aR,4S,4aS,6R,11S,12S,12aR,12bS)-12-benzoyloxy-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-triethylsilyloxy-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)diyl diacetate 
• 150665-56-8 7-O-triethylsilyl-13-keto baccatin III 
• 155588-18-4 C₄₁H₅₄N₂O₁₁SSi 
• 439813-57-7 (2'R,3'S)-2'-ethoxyethyl-7-triethylsilyl taxol 
• 135365-62-7 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate] 
• 181420-42-8 4-O-butyryl-4,10-dideacetyl-7-O-triethylsilylbaccatin III 
• 181420-18-8 4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III 
• 300833-61-8 2-debenzoyl-2-(3-methylbut-2-enoyl)paclitaxel 
• 32981-89-8 13-oxobaccatin III 
• 181423-36-9 13-deoxy-4,10-dideacetyl-13-oxo-4-O-propionyl-7-O-triethylsilylbaccatin III 
• 201283-46-7 13-deozy-4,10-dideacetyl-13-oxo-4-O-pentanoyl-7-O-triethylsilylbaccatin III 
• 181423-48-3 4-O-butyryl-13-deoxy-4,10-dideacetyl-13-oxo-7-O-triethylsilylbaccatin III 

Relevant articles and documents

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

A series of novel taxane-based multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized. Structure - activity relationship (SAR) study clearly indicates that modification of the C-7 position with hydrophobic arenecarbonylcinnamoyl groups brings about high potency against drug efflux mediated by P-glycoprotein (P-gp). Six TRAs exhibit ability to modulate a wide range of ATP-binding cassette (ABC) transporters, such as P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP), which may serve as novel broad-spectrum modulators of ABC transporters.

A new method to modify the C-4 position of 10-deacetylbaccatin III

We have developed a new method to modify the C-4 position of 10- deacetylbaccatin III (5) using the C-4 acetoxy anion of the 13-keto derivative (7) and various alkyl halides. The method developed herein should be very useful for the preparation of C-4 mod

Total synthesis of Taxol. 1. Retrosynthesis, degradation, and reconstitution

A successful strategy for the enantioselective synthesis of the natural stereoisomer of Taxol (1) has been developed. This strategy utilized the convergent assembly of Taxol's central eight-membered B ring from preformed synthons for rings A (10) and C (9) followed by late introduction of the D ring and side chain. Degradative studies confirmed the viability of certain crucial manipulations including oxidation of the C13 position (35 → 3) and regioselective introduction of the C1-hydroxyl, C2-benzoyloxy moiety (29 → 31). Additionally, a convenient method for the large-scale production of 29, a derivative useful for C2 analog production, was developed.