155625-49-3Relevant academic research and scientific papers
The synthesis and antitumor evaluation of unsymmetrical bis-imides
Cherney, Robert J.,Swartz, Stephen G.,Patten, Arthur D.,Akamike, Emeka,Sun, Jung-Hui,Kaltenbach III, Robert F.,Seitz, Steven P.,Behrens, Carl H.,Getahun, Zelleka,Trainor, George L.,Vavala, Mike,Kirshenbaum, Mindy R.,Papp, Lisa M.,Stafford, Margaret P.,Czerniak, Philip M.,Diamond, Richard J.,McRipley, Ronald J.,Page, Roni J.,Gross, Janet L.
, p. 163 - 168 (2007/10/03)
Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a potent, water soluble antitumor agent.
