15563-73-2

Upstream product

• 55-21-0 benzamide 
• 104-88-1 4-chlorobenzaldehyde 
• 15563-65-2 N-benzoyl-1-methoxy-1-(p-chlorophenyl)-methylamine 

Downstream Products

• 1201762-45-9 C₁₈H₂₁ClNO₄P 
• 1163684-20-5 (2R,3S)-2-benzyloxy-3-benzoylamino-3-(4-chlorophenyl)propanal 
• 1254529-23-1 C₂₁H₂₂ClN₃O 
• 1254529-05-9 C₂₁H₂₂ClN₃O 
• 1254529-46-8 C₂₄H₂₆ClN₃O 

Relevant academic research and scientific papers

A convenient one-pot approach to Paclitaxel (Taxol) side chain via 1,3-dipolar cycloaddition of carbonyl ylides and N-benzoylbenzyl imines

An efficient cascade approach to α-hydroxy-β-amino acid derivatives is reported, which goes through a 1,3-dipolar cycloaddition of carbonyl ylides and N-benzoylbenzyl imines and followed by hydrolysis under acidic conditions. This is the first example of using N-benzoylbenzyl imine as dipolarophile for 1,3-dipolar cycloaddition with carbonyl ylide, which provides a direct and convenient access for the one-pot synthesis of paclitaxel side chain and its derivatives.

Heterobimetallic Ir-Sn catalysis: Aza-Friedel-Crafts reaction of N-sulfonyl aldimines

The heterobimetallic complex [Ir(COD)(SnCl3)Cl(μ-Cl)] 2 catalyzes the aza-Friedel-Crafts reaction of 1,3,5- trimethoxybenzene, as well as substituted indoles with N-sulfonyl aldimines leading to the formation of diarylamines and triarylmethanes in good yields. The symmetrical triarylmethanes were also obtained from diarylamines and suitable nucleophiles via simultaneous cleavage of sp3 C-N bond and elimination of 1,3,5-trimethoxybenzene.